无菌状态与N-甲基-N'-硝基-N-亚硝基胍诱导结肠肿瘤
Germ-free status and colon tumor induction by N-methyl-N'-nitro-N-nitrosoguanidine.
作者信息
Weisburger J H, Reddy B S, Narisawa T, Wynder E L
出版信息
Proc Soc Exp Biol Med. 1975 Apr;148(4):1119-21. doi: 10.3181/00379727-148-38700.
Female germfree and conventional rats of 50 days of age were injected intrarectally with MNNG for 20 wk (total dose, 48 mg/rat) and autopsied 30 wk after last injection. The colon adenomas induced by MNNG were doubled in germfree rats compared to conventional animals. However, germfree status had no effect on the incidence of adenocarcinomas. It is concluded that pharmacodynamics and metabolism of carcinogen play a role greater than the immune status of the animal in the action of carcinogens such as MNNG.
对50日龄的雌性无菌大鼠和普通大鼠经直肠注射N-甲基-N'-硝基-N-亚硝基胍（MNNG），持续20周（总剂量为48mg/只大鼠），并在最后一次注射后30周进行解剖。与普通动物相比，无菌大鼠中由MNNG诱导的结肠腺瘤数量增加了一倍。然而，无菌状态对腺癌的发生率没有影响。得出的结论是，在MNNG等致癌物的作用中，致癌物的药效学和代谢比动物的免疫状态发挥着更大的作用。
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