[青岛市成年双胞胎血清脂质的遗传度分析]

[Heritability analysis on serum lipids of adult twins in Qingdao City].

作者信息

Lan Jinfeng, Pang Zengchang, Wang Shaojie, Zhang Haiping, Duan Haiping, Zhang Dong, Tan Qihua, Zhang Dongfeng

机构信息

Department of Public Health of Qingdao University Medical College, Qingdao 266021, China.

出版信息

Wei Sheng Yan Jiu. 2010 May;39(3):291-4.

PMID:20568455

Abstract

OBJECTIVE

To study the level and heritability of serum total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C) and triglycerides (TG) in adult twins sampled from Qingdao City of China.

METHODS

316 pairs of healthy twin aged 18 to 60 years were recruited from the database of Qingdao City twin registry. Fasting serum lipids were detected by automatic biochemical analyzer. The zygosity of twins was established by using polymorphic DNA-based microsatellite markers. The heritability was estimated by formulating univariate ACE twin mode in Mx soft.

RESULTS

The average levels of fasting serum TC, HDL-C, LDL-C and TG were (4.52 +/- 1.08), (1.46 +/- 0.39), (2.58 +/- 0.79) and (1.11 +/- 0.77) mmol/L, respectively. The best fitting models adjusted by sex and age in Mx soft were AE model for TC, HDL-C and LDL-C, whereas CE model for TG. The heritability of TC, HDL-C, LDL-C and TG were 53% , 62% , 57% and 0, respectively.

CONCLUSION

It is considered that both genetic and environmental factors may influence the level of TC, HDL-C and LDL-C, whereas environmental effect may be the factor essential for the level of TG.

摘要

目的

研究从中国青岛市抽取的成年双胞胎血清总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）和甘油三酯（TG）的水平及遗传度。

方法

从青岛市双胞胎登记数据库中招募316对年龄在18至60岁的健康双胞胎。采用自动生化分析仪检测空腹血脂。利用基于多态性DNA的微卫星标记确定双胞胎的合子性。通过在Mx软件中构建单变量ACE双胞胎模型估计遗传度。

结果

空腹血清TC、HDL-C、LDL-C和TG的平均水平分别为（4.52±1.08）、（1.46±0.39）、（2.58±0.79）和（1.11±0.77）mmol/L。Mx软件中经性别和年龄调整的最佳拟合模型，TC、HDL-C和LDL-C为AE模型，而TG为CE模型。TC、HDL-C、LDL-C和TG的遗传度分别为53%、62%、57%和0。