Heaney Robert P, Weaver Connie M
Department of Medicine, Creighton University Medical Center, Omaha, NE 68131, USA.
Endocrinol Metab Clin North Am. 2003 Mar;32(1):181-94, vii-viii. doi: 10.1016/s0889-8529(02)00063-4.
Calcium and vitamin D are essential for bone maintenance and for treatment-induced bone augmentation. Deficiencies of both nutrients are very common in the age group most afflicted by osteoporosis. Calcium enhancement of estrogen's effects now have been clearly demonstrated. Additionally, all currently approved bone active agents have been tested only in the presence of extra calcium, and newer anabolic agents create a skeletal need for mineral that will require even higher levels of calcium repletion. Prudent nutritional support for osteoporosis prevention and treatment consists of 30 to 40 mmol Ca/d together with sufficient vitamin D to maintain serum 25(OH)D levels above 80 nmol/L (i.e., approximately 25 microg vitamin D/d).
钙和维生素D对于维持骨骼健康以及治疗诱导的骨量增加至关重要。在受骨质疏松症影响最严重的年龄组中，这两种营养素的缺乏非常普遍。现已明确证实钙可增强雌激素的作用。此外，所有目前已获批的骨活性药物仅在额外补充钙的情况下进行过测试，而新型合成代谢药物会增加骨骼对矿物质的需求，这将需要更高水平的钙补充。对骨质疏松症预防和治疗的合理营养支持包括每日补充30至40毫摩尔钙以及充足的维生素D，以维持血清25(OH)D水平高于80纳摩尔/升（即约每日25微克维生素D）。
