Nelson Marilu, Perry Deborah, Ginsburg Glen, Sanger Warren G, Neff James R, Bridge Julia A
Department of Pediatrics, University of Nebraska Medical Center, Omaha, NE, USA.
Cancer Genet Cytogenet. 2003 Apr 15;142(2):142-4. doi: 10.1016/s0165-4608(02)00805-1.
Nonossifying fibroma is a benign, lytic lesion of fibrous origin most often observed in the metaphyseal region of the long bones in children and adolescents. It is frequently asymptomatic and is often characterized by a history of spontaneous resolution. Herein, we report a clinicohistopathologically typical case of nonossifying fibroma arising in the tibia of an 18-year-old skeletally mature female. Conventional cytogenetic analysis revealed a reciprocal translocation involving bands 1p31 and 4q34 [t(1;4)(p31;q34)]. To the best of our knowledge, this is only the second reported case of a clonally aberrant nonossifying fibroma.
