Berk Erhan, Aydogan Baykara Rabia
Department of Pediatrics, Malatya Turgut Ozal University, 44210 Malatya, Turkey.
Department of Physical Medicine and Rehabilitation, Malatya Turgut Ozal University, 44210 Malatya, Turkey.
J Clin Med. 2024 Sep 27;13(19):5751. doi: 10.3390/jcm13195751.
Fibrous cortical defect (FCD) and non-ossifying fibroma (NOF) are incidentally recognised and benign developmental lesions. The objective of this study was to ascertain the clinical manifestations and symptoms of FCDs/NOFs in children and adolescent patients, to characterise the lesions radiologically using X-ray and MRI techniques, and to determine the relationship between physical activity and the condition. The study included patients under the age of 18 with radiological lesions on their extremities. The lesions were classified as FCD or NOF in accordance with the distinctive imaging features. For each lesion, the bone involved, the site involved, the size of the lesion, and the type of lesion (according to the Ritschl classification) were recorded. In the anamnesis, the patient's presenting complaint, the character of the pain, if any, and the level of activity were investigated. Pain was quantified using the visual analogue scale (VAS) and the 21-Numbered Circle VAS (21-NCVAS). The 21-Numbered Circle Activity Scale (21-NCAS) and the International Physical Activity Questionnaire (IPAQ) were employed for the assessment of physical activity. The study included 34 lesions in 28 children (14 girls/14 boys). There was no difference in age between girls and boys ( = 0.45). According to Ritschl's classification, 18 (52.9%) lesions were stage A, 9 (26.5%) were stage B, and 7 (20.6%) were stage C. The lesion size increased with increasing Ritschl stage ( < 0.02). The main presenting complaint was pain (n = 13, 49.9%). In 21.4% of the children (n = 6), lesions were detected incidentally on radiographs. According to IPAQ, 39.3% of the children were physically inactive. There was a significant negative correlation between 21-NCAS and Ritschl stage (r = -0.51, < 0.05). Activity decreased as the Ritschl stage increased. There was a significant negative correlation between 21-NCAS and VAS (r = -0.69, < 0.05). Spontaneous pain was observed in 49.9% of patients diagnosed with FCD/NOF. No correlation was identified between lesion size and the presence or severity of pain. As the severity of pain and Ritschl stage increased, there was a corresponding decrease in physical activity.
纤维皮质缺损（FCD）和非骨化性纤维瘤（NOF）是偶然发现的良性发育性病变。本研究的目的是确定儿童和青少年患者中FCDs/NOFs的临床表现和症状，使用X射线和MRI技术对病变进行放射学特征描述，并确定体力活动与该疾病之间的关系。该研究纳入了18岁以下四肢有放射学病变的患者。根据独特的影像学特征将病变分类为FCD或NOF。记录每个病变所累及的骨骼、部位、病变大小以及病变类型（根据里施尔分类法）。在问诊中，调查患者的主诉、是否有疼痛及其性质以及活动水平。使用视觉模拟量表（VAS）和21点数字环形VAS（21-NCVAS）对疼痛进行量化。使用21点数字活动量表（21-NCAS）和国际体力活动问卷（IPAQ）评估体力活动。该研究纳入了28名儿童（14名女孩/14名男孩）的34个病变。女孩和男孩的年龄无差异（P = 0.45）。根据里施尔分类法，18个（52.9%）病变为A期，9个（26.5%）为B期，7个（20.6%）为C期。病变大小随里施尔分期增加而增大（P < 0.02）。主要主诉为疼痛（n = 13，49.9%）。21.4%的儿童（n = 6）在X线片上偶然发现病变。根据IPAQ，39.3%的儿童体力活动不足。21-NCAS与里施尔分期之间存在显著负相关（r = -0.51，P < 0.05）。随着里施尔分期增加，活动量减少。21-NCAS与VAS之间存在显著负相关（r = -0.69，P < 0.05）。在诊断为FCD/NOF的患者中，49.9%观察到自发疼痛。未发现病变大小与疼痛的存在或严重程度之间存在相关性。随着疼痛严重程度和里施尔分期增加，体力活动相应减少。
