Massara Cristiano Lara, Ferreira Rafaela Salgado, de Andrade Luiz Dias, Guerra Henrique Leonardo, Carvalho Omar dos Santos
Laborat rio de Helmintoses Intestinais, Centro de Pesquisas Ren Rachou, Funda o Oswaldo Cruz, Belo Horizonte, MG, 30190-002, Brasil.
Cad Saude Publica. 2003 Jan-Feb;19(1):335-40. doi: 10.1590/s0102-311x2003000100039. Epub 2003 Apr 1.
Ascaris lumbricoides infection is acquired via ingestion of embryonated eggs of the parasite, thus justifying the search for ovicidal compounds. We studied the effect of 16 household and laboratory detergents and disinfectants on the embryogenesis of this helminth. Children carrying this infection were treated with levamisole. Eliminated female worms were collected and dissected to obtain eggs from the uteri. The eggs were placed in contact with various products at different dilutions and for various periods of time. After washing, eggs were incubated at 28 grades C for 20 days, for viability tests and to determine the embryonation rate. Only one product completely inhibited the embryonation of eggs at every dilution and for every time period tested. Five products inhibited more than 50% of embryonation, while six inhibited less than 50%. Three products showed no effect on embryonation, while for one the percentage of embryonated eggs was higher than in the control tubes.
蛔虫感染是通过摄入寄生虫的感染性虫卵而获得的,因此有理由寻找杀卵化合物。我们研究了16种家用和实验室洗涤剂及消毒剂对这种蠕虫胚胎发育的影响。对携带这种感染的儿童用左旋咪唑进行治疗。收集并解剖排出的雌虫以从子宫中获取虫卵。将虫卵与不同稀释度的各种产品接触不同时间。洗涤后,将虫卵在28摄氏度下孵育20天,进行活力测试并确定胚胎发育率。在每个测试的稀释度和时间段,只有一种产品完全抑制了虫卵的胚胎发育。五种产品抑制了超过50%的胚胎发育,而六种产品抑制率低于50%。三种产品对胚胎发育没有影响,而有一种产品中感染性虫卵的百分比高于对照管。