Orr H Allen
Department of Biology, University of Rochester, Rochester, New York 14627, USA.
Genetics. 2003 Apr;163(4):1519-26. doi: 10.1093/genetics/163.4.1519.
We know little about the distribution of fitness effects among new beneficial mutations, a problem that partly reflects the rarity of these changes. Surprisingly, though, population genetic theory allows us to predict what this distribution should look like under fairly general assumptions. Using extreme value theory, I derive this distribution and show that it has two unexpected properties. First, the distribution of beneficial fitness effects at a gene is exponential. Second, the distribution of beneficial effects at a gene has the same mean regardless of the fitness of the present wild-type allele. Adaptation from new mutations is thus characterized by a kind of invariance: natural selection chooses from the same spectrum of beneficial effects at a locus independent of the fitness rank of the present wild type. I show that these findings are reasonably robust to deviations from several assumptions. I further show that one can back calculate the mean size of new beneficial mutations from the observed mean size of fixed beneficial mutations.
我们对新的有益突变之间适合度效应的分布了解甚少,这个问题部分反映了这些变化的稀有性。然而,令人惊讶的是,群体遗传学理论使我们能够在相当一般的假设下预测这种分布应该是什么样的。利用极值理论,我推导出了这种分布,并表明它有两个意想不到的特性。第一,一个基因处有益适合度效应的分布是指数分布。第二,一个基因处有益效应的分布具有相同的均值,而与当前野生型等位基因的适合度无关。因此,新突变产生的适应性具有一种不变性的特征:自然选择在一个位点上从相同的有益效应谱中进行选择,而与当前野生型的适合度等级无关。我表明,这些发现对于偏离几个假设的情况具有相当的稳健性。我进一步表明,可以从观察到的固定有益突变的平均大小反推新的有益突变的平均大小。