通过生长调节素C放射受体分析法检测羊水反应性：与生长激素、催乳素及胎儿肾脏成熟度的相关性

Amniotic fluid reactivity detected by somatomedin C radioreceptor assay: correlation with growth hormone, prolactin and fetal renal maturation.

作者信息

Chochinov R H, Ketupanya A, Mariz I K, Underwood L E, Daughaday W H

出版信息

J Clin Endocrinol Metab. 1976 May;42(5):983-6. doi: 10.1210/jcem-42-5-983.

Abstract

Amniotic fluid was assayed by a radioreceptor assay utilizing 125I-somatomedin C and placental membranes. Growth hormone and prolactin levels were measured by radioimmunoassay at different gestational ages (8-41 weeks). Somatomedin receptor activity, growth hormone, and prolactin reached high levels during early gestation (8-26 weeks) displaying different patterns of appearance which reflect fetal serum levels of these hormones. After 26 weeks gestation all these hormones decreased in concentration. This decrease showed a strong correlation with fetal renal maturation as measured by amniotic fluid creatinine levels.

摘要

利用¹²⁵I-生长调节素C和胎盘膜通过放射受体分析法对羊水进行检测。在不同孕周（8 - 41周）通过放射免疫分析法测定生长激素和催乳素水平。生长调节素受体活性、生长激素和催乳素在妊娠早期（8 - 26周）达到高水平，呈现出不同的出现模式，这反映了这些激素的胎儿血清水平。妊娠26周后，所有这些激素的浓度均下降。这种下降与通过羊水肌酐水平测定的胎儿肾脏成熟度密切相关。