Lara González Alma Lina, Martínez Jaimes Alejandro, Romero Arauz Juan Fernando
Hospital de Ginecoobstetricia Luis Castelazo Ayala I.M.S.S., Servicio de Complicaciones Hipertensivas del Embarazo.
Ginecol Obstet Mex. 2003 Feb;71:82-6.
Many markers have been proposed to identify the pregnant woman at risk to develop preeclampsia, without finding at the moment the gold standard.
The main purpose of the present study was to know if the detection of microalbuminuria in early stages of pregnancy is a good predictor of preeclampsia.
One hundred and two women (102) were studied. All of them had risk factors for preeclampsia with a pregnancy between 16 and 18 weeks, an evaluation of microalbuminuria was done through a clean-catch dipstick of the first miction of the day, excluding patients with urinary tract infections and nephropaty, > 20 mg/L was considered a positive value. Diagnosis data of preeclampsia were recopilated from the clinical chart of each patient after the pregnancy was resolved.
Of the 102 patients, 53 had a negative microalbuminuria, 6 (11%) developed preeclampsia and 47 (88%) did not. Forty nine women had positive microalbuminuria and 23 (46.9%) of them developed preeclampsia and 26 (53%) did not. The sensitivity was 79%, specificity 63%, the positive predictive value was 46% and the negative predictive value was 88%.
The detection of microalbuminuria in early stages of pregnancy could be a good predictor of preeclampsia, moreover it is a simple and feasible procedure to do by the obstetrician.
已经提出了许多标志物来识别有发生先兆子痫风险的孕妇，但目前尚未找到金标准。
本研究的主要目的是了解孕期早期微量白蛋白尿的检测是否是先兆子痫的良好预测指标。
对102名女性进行了研究。她们均有先兆子痫的风险因素，妊娠周数在16至18周之间，通过当日首次晨尿的清洁中段尿试纸法评估微量白蛋白尿，排除尿路感染和肾病患者，>20mg/L被视为阳性值。妊娠结束后，从每位患者的临床病历中收集先兆子痫的诊断数据。
102例患者中，53例微量白蛋白尿阴性，其中6例（11%）发生先兆子痫，47例（88%）未发生。49例女性微量白蛋白尿阳性，其中23例（46.9%）发生先兆子痫，26例（53%）未发生。敏感性为79%，特异性为63%，阳性预测值为46%，阴性预测值为88%。
孕期早期微量白蛋白尿的检测可能是先兆子痫的良好预测指标，此外，这是产科医生可以进行的简单可行的操作。
