Garovic Vesna D, Wagner Steven J, Turner Stephen T, Rosenthal David W, Watson William J, Brost Brian C, Rose Carl H, Gavrilova Larisa, Craigo Paula, Bailey Kent R, Achenbach Johannes, Schiffer Mario, Grande Joseph P
Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN 55905, USA.
Am J Obstet Gynecol. 2007 Apr;196(4):320.e1-7. doi: 10.1016/j.ajog.2007.02.007.
The objective of this study was to examine whether podocyturia, which is the urinary excretion of viable podocytes (glomerular epithelial cells), is present in urinary sediments of patients with preeclampsia. We also aimed to compare the test characteristics of podocyturia to those angiogenic factors that have been shown to play an important role in the pathogenesis of preeclampsia (s-Flt-1, PlGF, and endoglin).
Serum angiogenic factors were measured in 44 patients with preeclampsia and 23 normotensive control patients. In a patient subset (15 cases and 16 control patients), urinary proteinuria were identified and quantified on the basis of their expressions of podocyte-specific proteins.
Urinary podocyte excretion occurred in all patients with preeclampsia. The positive predictive value for the diagnosis of preeclampsia was greater for podocyturia than for any of the measured angiogenic factors.
Podocyturia is a highly sensitive and specific marker for preeclampsia. It may contribute to the development of proteinuria in preeclampsia.
本研究的目的是检测先兆子痫患者尿沉渣中是否存在足细胞尿，即存活足细胞（肾小球上皮细胞）的尿排泄。我们还旨在比较足细胞尿与那些已被证明在先兆子痫发病机制中起重要作用的血管生成因子（可溶性血管内皮生长因子受体-1、胎盘生长因子和内皮糖蛋白）的检测特征。
对44例先兆子痫患者和23例血压正常的对照患者测定血清血管生成因子。在一个患者亚组（15例病例和16例对照患者）中，根据足细胞特异性蛋白的表达对尿蛋白尿进行鉴定和定量。
所有先兆子痫患者均出现尿足细胞排泄。足细胞尿对先兆子痫诊断的阳性预测值高于任何测量的血管生成因子。
足细胞尿是先兆子痫的一种高度敏感和特异的标志物。它可能导致先兆子痫患者蛋白尿的发生。
