Singh N P, Thind I S, Vitale L F, Pawlow M
J Lab Clin Med. 1976 Feb;87(2):273-80.
Three groups of Wistar rats (5 males and 5 females in each group) were given zero, 100 mg., and 200 mg. Pb(NO3) 2 per kilogram of body weight per day for 45 days and were mated. The lead feeding was continued throughout the duration of experiments. The blood and urinary lead, blood aminolevulinic acid dehydratase activity, and free erythrocyte protoporphyrin and urinary aminolevulinic acid were measured on these rats at the beginning of the study, at the time of mating, and prior to delivery. The tissues, incuding kidney, liver, heart, and brain of the newborn progeny were analyzed for lead content. The blood lead and aminolevulinic acid dehydratase were also measured (pooled blood). These tissues contained very high amounts of lead when the newborns were killed within half an hour after their birth, a very significant reduction being found after one day with further reduction after 7 days. Kidney and heart contained the highest amount of lead, the levels being dose-related. Three weeks after birth the lead content of tissues rose significantly but blood concentrations remained almost identical to the levels obtained 1 day after birth. There was no evidence of lead accumulation in the brain of the babies...
将三组Wistar大鼠（每组5只雄性和5只雌性）每天按每千克体重给予0、100毫克和200毫克的硝酸铅，持续45天，然后进行交配。在整个实验期间持续给予铅。在研究开始时、交配时和分娩前对这些大鼠测量血液和尿液中的铅、血液氨基乙酰丙酸脱水酶活性、游离红细胞原卟啉和尿液氨基乙酰丙酸。对新生后代的组织，包括肾脏、肝脏、心脏和大脑进行铅含量分析。还测量了血液铅和氨基乙酰丙酸脱水酶（混合血液）。当新生儿在出生后半小时内被处死时，这些组织含有非常高的铅量，在一天后发现有非常显著的减少，7天后进一步减少。肾脏和心脏含铅量最高，含量与剂量相关。出生三周后，组织中的铅含量显著上升，但血液浓度几乎与出生后1天测得的水平相同。没有证据表明婴儿大脑中有铅蓄积……
