Malhotra K M, Shukla G S, Chandra S V
Arch Toxicol. 1982 Mar;49(3-4):331-6. doi: 10.1007/BF00347881.
Rats were coexposed to lead (Pb) and Copper (Cu) through drinking water and intraperitoneally, respectively, for a period of 21 days. Neurochemical studies in these rats showed significant reduction in the activity of adenosine triphosphatase, cytochrome-c-oxidase, diaphorase and in the levels of biogenic amines in the rats simultaneously exposed to the two metals compared to either of the metal alone. These neurotoxic effects were not related to the contents of either of the metals in the brain since their accumulation after combined exposure was much less than observed after individual exposure to Pb or Cu.
大鼠分别通过饮用水和腹腔注射的方式同时接触铅（Pb）和铜（Cu），持续21天。对这些大鼠进行的神经化学研究表明，与单独接触任何一种金属相比，同时接触两种金属的大鼠体内三磷酸腺苷酶、细胞色素c氧化酶、黄递酶的活性以及生物胺水平均显著降低。这些神经毒性作用与大脑中任何一种金属的含量均无关，因为联合接触后它们在大脑中的蓄积量远低于单独接触铅或铜后的观察值。
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