Dhir V, Dhand P
Assistant Professor, Post Graduate Department of Chemistry, G.H.G Khalsa College, Gurusar Sardhar-Ludhiana-141004 (Affiliated to Punjab University, Chandigarh), India.
Toxicol Int. 2010 Jan;17(1):1-7. doi: 10.4103/0971-6580.68340.
Lead being a toxic cumulative poison and an environmental pollutant, experiments were conducted at an oral chronic dose of (60 mg/kg/day) for 90 days on adult female rats (Rattus Norvegicus) and its effect on the reproductive functions in relation to the biochemical effects was studied. It was observed that the chronic dose of lead caused an elevation in the level of proteins, acid phosphatase, alkaline phosphatase, alanine aminotransferase, and aspartate aminotransferase in all the soft tissues studied indicating tissue damage. It also inhibited the level of acetylcholinesterase in all the tissues. Fertility tests by pairing treated females with males showed that lead-treated female showed irregular estrous cycle and the fertility rate dropped to 40% as female pups of lead-treated mothers showed loss in weight, high mortality rate, poor growth rate, and late vaginal opening. Histological studies of ovary showed atresia in all the stages of folliculogenesis sustaining the poor fertility observations. The present study revealed that lead caused great tissue damage and affected reproductive performance of female rats at a chronic dose.
铅是一种有毒的累积性毒物和环境污染物，对成年雌性大鼠（褐家鼠）以口服慢性剂量（60毫克/千克/天）进行了为期90天的实验，并研究了其对生殖功能的影响以及相关的生化效应。观察到，铅的慢性剂量导致所研究的所有软组织中的蛋白质、酸性磷酸酶、碱性磷酸酶、丙氨酸氨基转移酶和天冬氨酸氨基转移酶水平升高，表明组织受损。它还抑制了所有组织中的乙酰胆碱酯酶水平。通过将经处理的雌性与雄性配对进行生育力测试，结果显示，经铅处理的雌性表现出不规则的发情周期，生育力降至40%，因为经铅处理的母亲所生的雌性幼崽体重减轻、死亡率高、生长率低且阴道开口延迟。卵巢的组织学研究显示，在卵泡发生的所有阶段均出现闭锁，这支持了生育力不佳的观察结果。本研究表明，铅在慢性剂量下会对雌性大鼠造成严重的组织损伤并影响其生殖性能。
