Epstein M, Pins D S, Schneider N, Levinson R
J Lab Clin Med. 1976 May;87(5):822-39.
Previous studies from this laboratory have demonstrated that the redistribution of blood volume and concomitant central hypervolemia induced by water immersion to the neck (NI) results in a significant natriuresis, kaliuresis, and diuresis. The NI model was utilized to assess the role of "effective volume" and hyperaldosteronism in the impairment of sodium and water handling in cirrhosis. Eleven cirrhotic patients were studied twice while in balance on a 10 mEq. Na, 100 mEq. K diet: control and NI. The conditions of seated posture and time of day were identical. UNaV was constant throughout C, ranging from 1 to 2 muEq per minute. During NI, UNaV increased progressively from 1 +/- 1 (S.E.M.) during the prestudy hour to 89 +/- 32 muEq per minute during hour 5 of NI (p less than 0.02), greatly exceeding the comparable value found in normal subjects on an identical diet. (See article).
本实验室先前的研究表明，水浸至颈部（NI）所引起的血容量重新分布及随之而来的中枢性血容量过多会导致显著的尿钠排泄、尿钾排泄和利尿。NI模型被用于评估“有效血容量”和醛固酮增多症在肝硬化患者钠和水代谢障碍中的作用。11例肝硬化患者在摄入10 mEq钠、100 mEq钾饮食达到平衡状态时接受了两次研究：分别为对照期和NI期。坐姿和一天中的时间条件均相同。在整个对照期，尿钠排泄率（UNaV）保持恒定，每分钟为1至2 μEq。在NI期，UNaV从研究前1小时的1±1（标准误）逐渐增加至NI期第5小时的89±32 μEq每分钟（p<0.02），大大超过了摄入相同饮食的正常受试者的相应值。（见文章）
