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Reversion of the M184V mutation in simian immunodeficiency virus reverse transcriptase is selected by tenofovir, even in the presence of lamivudine.即使在拉米夫定存在的情况下，替诺福韦也能选择出猿猴免疫缺陷病毒逆转录酶中M184V突变的回复突变。
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Early and persistent bone marrow hematopoiesis defect in simian/human immunodeficiency virus-infected macaques despite efficient reduction of viremia by highly active antiretroviral therapy during primary infection.尽管在初次感染期间通过高效抗逆转录病毒疗法有效降低了病毒血症，但猿猴/人类免疫缺陷病毒感染的猕猴仍存在早期且持续的骨髓造血缺陷。
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Post-exposure prophylaxis with highly active antiretroviral therapy could not protect macaques from infection with SIV/HIV chimera.使用高效抗逆转录病毒疗法进行暴露后预防并不能保护猕猴免受SIV/HIV嵌合体的感染。
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Long-lasting recovery in CD4 T-cell function and viral-load reduction after highly active antiretroviral therapy in advanced HIV-1 disease.高效抗逆转录病毒疗法治疗晚期HIV-1疾病后CD4 T细胞功能的持久恢复及病毒载量降低
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Antiretroviral drug resistance testing in adults with HIV infection: implications for clinical management. International AIDS Society--USA Panel.成人HIV感染者的抗逆转录病毒药物耐药性检测：对临床管理的影响。国际艾滋病学会美国小组。
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猿猴免疫缺陷病毒对蛋白酶抑制剂的敏感性。

Susceptibilities of simian immunodeficiency virus to protease inhibitors.

作者信息

Giuffre Angelica C, Higgins Joanne, Buckheit Robert W, North Thomas W

机构信息

Center for Comparative Medicine, Department of Veterinary Molecular Biosciences, University of California, Davis, Davis, California 95616, USA.

出版信息

Antimicrob Agents Chemother. 2003 May;47(5):1756-9. doi: 10.1128/AAC.47.5.1756-1759.2003.

DOI:10.1128/AAC.47.5.1756-1759.2003
PMID:12709355
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC153320/
Abstract

We used a focal infectivity assay with HeLa H1-JC.37 cells to directly compare susceptibilities of simian immunodeficiency virus (SIV) and human immunodeficiency virus type 1 (HIV-1) to protease inhibitors. SIVmac239 was inhibited by indinavir, saquinavir, and ritonavir, with 50% effective concentrations (means +/- standard deviations) of 39 +/- 8, 55 +/- 3, and 13 +/- 5 nM, respectively. The corresponding values for inhibition of HIV-1 were 66 +/- 4, 47 +/- 10, and 25 +/- 14 nM, respectively.

摘要

我们使用针对HeLa H1-JC.37细胞的局部感染性测定法，直接比较猿猴免疫缺陷病毒（SIV）和1型人类免疫缺陷病毒（HIV-1）对蛋白酶抑制剂的敏感性。茚地那韦、沙奎那韦和利托那韦可抑制SIVmac239，其50%有效浓度（平均值±标准差）分别为39±8、55±3和13±5 nM。抑制HIV-1的相应值分别为66±4、47±10和25±14 nM。