Alonso-Valle H, Acha O, García-Palomo J D, Fariñas-Alvarez C, Fernández-Mazarrasa C, Fariñas M C
Division of Preventive Medicine, University of Cantabria, School of Medicine, Santander, Spain.
Eur J Clin Microbiol Infect Dis. 2003 Apr;22(4):254-7. doi: 10.1007/s10096-003-0890-x. Epub 2003 Mar 22.
The present study was conducted in order to assess the epidemiology and clinical course of candidemia and to identify the risk factors associated with mortality. A total of 143 episodes of nosocomial candidemia were identified during a 5-year period, and these were included in the study. The majority of candidemic episodes were due to Candida albicans (63, 44%), followed by Candida parapsilosis(32, 22%). The overall mortality was 45%. The following independent prognostic factors for mortality were identified: bacterial sepsis, rapidly fatal illness, chronic obstructive lung disease, presence of a central venous catheter, candidemia due to Candida albicans, and lack of antifungal therapy.
本研究旨在评估念珠菌血症的流行病学和临床病程，并确定与死亡率相关的危险因素。在5年期间共识别出143例医院获得性念珠菌血症病例，并纳入本研究。大多数念珠菌血症病例由白色念珠菌引起（63例，44%），其次是近平滑念珠菌（32例，22%）。总死亡率为45%。确定了以下与死亡率相关的独立预后因素：细菌性败血症、快速致命性疾病、慢性阻塞性肺疾病、中心静脉导管的存在、白色念珠菌引起的念珠菌血症以及缺乏抗真菌治疗。
