Decreased relative brain tissue levels of inositol in fetal hydrocephalus.
作者信息
Kok René D, Steegers-Theunissen Régine P M, Eskes Tom K A B, Heerschap Arend, van den Berg Paul P
机构信息
Department of Obstetrics and Gynecology, University Medical Center Nijmegen, The Netherlands.
出版信息
Am J Obstet Gynecol. 2003 Apr;188(4):978-80. doi: 10.1067/mob.2003.206.
OBJECTIVE
Inositol seems to play a role in the development of the central nervous system. In this study, the brain tissue level of inositol in fetal hydrocephalus was compared with that of healthy control subjects.
STUDY DESIGN
Proton magnetic resonance spectroscopy was used to examine the inositol over creatine ratio in the brain of 10 hydrocephalic human fetuses and 36 normal control subjects.
RESULTS
Resolved signals for inositol and creatine were detected successfully in six hydrocephalic fetuses and in all control subjects. The inositol over creatine ratio was significantly lower in fetuses with hydrocephalus (P <.01).
CONCLUSION
This result supports speculations concerning the role of inositol in central nervous system development.
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