Girard Nadine, Fogliarini Céline, Viola Angèle, Confort-Gouny Sylviane, Fur Yann Le, Viout Patrick, Chapon Frédérique, Levrier Olivier, Cozzone Patrick
Service de Neuroradiologie, Assistance Publique-Hôpitaux de Marseille, Hôpital la Timone, Université de la Méditerranée, Marseille, France.
Eur J Radiol. 2006 Feb;57(2):217-25. doi: 10.1016/j.ejrad.2005.11.021. Epub 2006 Jan 18.
Cerebral maturation in the human fetal brain was investigated by in utero localized proton magnetic resonance spectroscopy (MRS). Spectra were acquired on a clinical MR system operating at 1.5 T. Body phased array coils (four coils) were used in combination with spinal coils (two coils). The size of the nominal volume of interest (VOI) was 4.5 cm(3) (20 mm x 15 mm x 15 mm). The MRS acquisitions were performed using a spin echo sequence at short and long echo times (TE = 30 ms and 135 ms) with a VOI located within the cerebral hemisphere at the level of the centrum semiovale. A significant reduction in myo-inositol and choline and an increase in N-acetylaspartate were observed with progressive age. The normal MR spectroscopy data reported here will help to determine whether brain metabolism is altered, especially when subtle anatomic changes are observed on conventional images. Some examples of impaired fetal brain development studied by MRS are illustrated.
通过宫内局部质子磁共振波谱（MRS）对人类胎儿脑的脑成熟度进行了研究。在一台1.5T的临床磁共振系统上采集波谱。体部相控阵线圈（四个线圈）与脊柱线圈（两个线圈）联合使用。名义感兴趣体积（VOI）的大小为4.5cm³（20mm×15mm×15mm）。使用自旋回波序列在短回波时间和长回波时间（TE = 30ms和135ms）下进行MRS采集，VOI位于半卵圆中心水平的脑半球内。随着年龄的增长，观察到肌醇和胆碱显著减少，N - 乙酰天门冬氨酸增加。这里报告的正常磁共振波谱数据将有助于确定脑代谢是否改变，特别是当在传统图像上观察到细微的解剖学变化时。文中还举例说明了通过MRS研究的胎儿脑发育受损情况。
