Heerschap Arend, Kok René D, van den Berg Paul P
Department of Radiology, University Medical Center St. Radboud, Geert Grooteplein Zuid 18, 6525 GA Nijmegen, The Netherlands.
Childs Nerv Syst. 2003 Aug;19(7-8):418-21. doi: 10.1007/s00381-003-0774-5. Epub 2003 Jun 17.
The assessment of metabolites in the human fetal brain in utero could have diagnostic value. We explored the feasibility and potentials of proton magnetic resonance spectroscopy ((1)H MRS) for this purpose.
(1)H MRS was successfully performed in the third trimester of pregnancy without using sedation. Signals for inositol, choline, creatine, and N-acetylasparatate (NAA) compounds were detected in MR spectra from single voxels in the brain. Absolute tissue levels of these metabolites resemble values measured in preterm and term babies, especially of relatively more mature brain regions, from which most of the MR spectra have been obtained. Brain maturation between 30 and 41 weeks of gestation was most clearly reflected by increasing levels of the neuronal marker NAA.
With proper care for the methodological aspects, antenatal (1)H MRS clearly has the potential to evolve into a clinical tool for assessing a number of key metabolites in the human fetal brain in utero.
评估子宫内人类胎儿大脑中的代谢物可能具有诊断价值。为此，我们探索了质子磁共振波谱（(1)H MRS）的可行性和潜力。
在妊娠晚期未使用镇静剂的情况下成功进行了(1)H MRS。在大脑单个体素的磁共振波谱中检测到了肌醇、胆碱、肌酸和N-乙酰天门冬氨酸（NAA）化合物的信号。这些代谢物的绝对组织水平类似于在早产儿和足月儿中测得的值，尤其是在大多数磁共振波谱所获取的相对更成熟的脑区。妊娠30至41周之间的大脑成熟最明显地通过神经元标志物NAA水平的升高得以体现。
在对方法学方面给予适当关注的情况下，产前(1)H MRS显然有潜力发展成为一种用于评估子宫内人类胎儿大脑中多种关键代谢物的临床工具。
