抗肿瘤剂。485. 海绵抑素6的分离与结构，一种来自海洋海绵Cribrochalina sp.的深蓝色癌细胞生长抑制剂。

Antineoplastic agents. 485. Isolation and structure of cribrostatin 6, a dark blue cancer cell growth inhibitor from the marine sponge Cribrochalina sp.

作者信息

Pettit George R, Collins Jeremiah C, Knight John C, Herald Delbert L, Nieman Ronald A, Williams Michael D, Pettit Robin K

机构信息

Cancer Research Institute and Department of Chemistry and Biochemistry, Arizona State University, Tempe, Arizona 85287-2404, USA.

出版信息

J Nat Prod. 2003 Apr;66(4):544-7. doi: 10.1021/np020012t.

DOI:10.1021/np020012t

PMID:12713412

Abstract

Cribrostatin 6, a dark blue cancer cell growth inhibiting (P388 ED(50) 0.3 microg/mL) constituent of the Republic of Maldives marine sponge Cribrochalina sp., has been assigned structure 3 on the basis of a combination of HRMS, high-field (500 MHz, HMBC, and GOESY experiments) (15)N, (1)H, and (13)C NMR, and X-ray crystal structure analyses. Cribrostatin 6 also was found to inhibit the growth of a number of pathogenic bacteria and fungi.

摘要

刺胞抑素6是马尔代夫海洋海绵Cribrochalina sp.中一种深蓝色的癌细胞生长抑制成分（P388 ED(50)为0.3微克/毫升），基于高分辨质谱（HRMS）、高场（500兆赫）的(15)N、(1)H和(13)C核磁共振（NMR）以及异核多键相关实验（HMBC）和全相关谱实验（GOESY），并结合X射线晶体结构分析，确定其结构为3。还发现刺胞抑素6能抑制多种致病细菌和真菌的生长。