• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

2型糖尿病患者在使用降脂药物方面的差异。

Disparities in use of lipid-lowering medications among people with type 2 diabetes mellitus.

作者信息

Safford Monika, Eaton Laura, Hawley Gerald, Brimacombe Michael, Rajan Mangala, Li Huiling, Pogach Leonard

机构信息

New Jersey Veterans Health Administration Healthcare System, East Orange, NJ, USA.

出版信息

Arch Intern Med. 2003 Apr 28;163(8):922-8. doi: 10.1001/archinte.163.8.922.

DOI:10.1001/archinte.163.8.922
PMID:12719201
Abstract

BACKGROUND

People with diabetes are at high risk for cardiovascular events regardless of known heart disease. Physicians may underrecognize the excess cardiovascular risk conferred by diabetes alone, without a recent cardiovascular event. Other disparities in the receipt of lipid-lowering medications (LLMs) may exist.

METHODS

We studied veterans with diabetes in fiscal years 1998 and 1999 cross-sectionally. We used administrative data (demographic information, International Classification of Diseases, Ninth Revision [ICD-9] codes, utilization information, medications, and laboratory tests) to evaluate associations between use of LLMs and age, ethnicity, sex, marital status, Charlson Index, heart disease ICD-9 codes, oral agents and insulin, hospitalization status, and low-density lipoprotein cholesterol levels. We constructed separate logistic regression models to evaluate associations between low-density lipoprotein cholesterol and similar predictor variables.

RESULTS

Odds ratios were similar in both years. For fiscal year 1999, patients without recent ICD-9 codes in their administrative data indicating heart disease were 0.35 times less likely to be given LLMs than those with such codes. Individuals older than 75 years were 0.65 times less likely to be given LLMs than those younger than 65 years. African Americans were 0.72 times less likely than whites to be given LLMs. In fiscal years 1999 and 1998, 27% and 36% of individuals given LLMs had low-density lipoprotein cholesterol levels higher than 130 mg/dL (3.37 mmol/L).

CONCLUSIONS

Veterans with diabetes but no recently coded heart disease, older individuals, and African Americans could benefit from programs targeted to introduce LLMs. Up to one third of individuals given LLMs remained above the target level of 130 mg/dL for low-density lipoprotein cholesterol.

摘要

背景

无论是否患有已知的心脏病,糖尿病患者发生心血管事件的风险都很高。医生可能未充分认识到仅由糖尿病导致的额外心血管风险,而患者近期又未发生心血管事件。在接受降脂药物(LLMs)治疗方面可能还存在其他差异。

方法

我们对1998财年和1999财年的糖尿病退伍军人进行了横断面研究。我们使用行政数据(人口统计学信息、国际疾病分类第九版[ICD - 9]编码、使用信息、药物和实验室检查结果)来评估降脂药物的使用与年龄、种族、性别、婚姻状况、查尔森指数、心脏病ICD - 9编码、口服药物和胰岛素、住院状态以及低密度脂蛋白胆固醇水平之间的关联。我们构建了单独的逻辑回归模型来评估低密度脂蛋白胆固醇与类似预测变量之间的关联。

结果

两年的比值比相似。对于1999财年,行政数据中没有近期ICD - 9编码表明患有心脏病的患者接受降脂药物治疗的可能性比有此类编码的患者低0.35倍。75岁以上的个体接受降脂药物治疗的可能性比65岁以下的个体低0.65倍。非裔美国人接受降脂药物治疗的可能性比白人低0.72倍。在1999财年和1998财年,接受降脂药物治疗的个体中分别有27%和36%的低密度脂蛋白胆固醇水平高于130 mg/dL(3.37 mmol/L)。

结论

患有糖尿病但近期无心脏病编码的退伍军人、老年人和非裔美国人可能会从旨在引入降脂药物的项目中受益。接受降脂药物治疗的个体中,高达三分之一的人的低密度脂蛋白胆固醇水平仍高于130 mg/dL的目标水平。

相似文献

1
Disparities in use of lipid-lowering medications among people with type 2 diabetes mellitus.2型糖尿病患者在使用降脂药物方面的差异。
Arch Intern Med. 2003 Apr 28;163(8):922-8. doi: 10.1001/archinte.163.8.922.
2
Racial and ethnic disparities in the control of cardiovascular disease risk factors in Southwest American veterans with type 2 diabetes: the Diabetes Outcomes in Veterans Study.美国西南部 2 型糖尿病退伍军人心血管疾病危险因素控制方面的种族和民族差异:退伍军人糖尿病结局研究
BMC Health Serv Res. 2006 May 23;6:58. doi: 10.1186/1472-6963-6-58.
3
Suboptimal control of lipid levels: results from the non-interventional Centralized Pan-Russian Survey of the Undertreatment of Hypercholesterolemia II (CEPHEUS II).血脂控制不理想:来自非干预性俄罗斯中央调查血脂异常治疗不足 II 期研究(CEPHEUS II)的结果。
Cardiovasc Diabetol. 2017 Dec 16;16(1):158. doi: 10.1186/s12933-017-0641-4.
4
Pharmacologic lipid-lowering therapy in type 2 diabetes mellitus: background paper for the American College of Physicians.2型糖尿病的药物降脂治疗:美国医师协会背景文件
Ann Intern Med. 2004 Apr 20;140(8):650-8. doi: 10.7326/0003-4819-140-8-200404200-00013.
5
Real-world data on metabolic effects of PCSK9 inhibitors in a tertiary care center in patients with and without diabetes mellitus.真实世界数据:在有或没有糖尿病的患者中,三级护理中心的 PCSK9 抑制剂对代谢的影响。
Cardiovasc Diabetol. 2021 Apr 24;20(1):89. doi: 10.1186/s12933-021-01283-w.
6
Effect of intensive glycemic control on fibrinogen, lipids, and lipoproteins: Veterans Affairs Cooperative Study in Type II Diabetes Mellitus.强化血糖控制对纤维蛋白原、脂质和脂蛋白的影响:美国退伍军人事务部II型糖尿病合作研究
Arch Intern Med. 1998;158(22):2485-90. doi: 10.1001/archinte.158.22.2485.
7
The management of type 2 diabetes mellitus: a novel approach for addressing glycemic and lipid control with colesevelam HCl.2型糖尿病的管理:一种使用盐酸考来维仑解决血糖和血脂控制问题的新方法。
Adv Nurse Pract. 2009 Nov;17(11):suppl 1-16.
8
Heart matters: Gender and racial differences cardiovascular disease risk factor control among veterans.心脏问题:退伍军人中性别和种族在心血管疾病危险因素控制方面的差异
Womens Health Issues. 2014 Sep-Oct;24(5):477-83. doi: 10.1016/j.whi.2014.05.005.
9
Efficacy and safety of ETC-1002, a novel investigational low-density lipoprotein-cholesterol-lowering therapy for the treatment of patients with hypercholesterolemia and type 2 diabetes mellitus.ETC-1002 治疗高胆固醇血症和 2 型糖尿病患者的疗效和安全性:一种新型的研究性低密脂蛋白胆固醇降低治疗药物。
Arterioscler Thromb Vasc Biol. 2014 Mar;34(3):676-83. doi: 10.1161/ATVBAHA.113.302677. Epub 2014 Jan 2.
10
Control of glycemia and other cardiovascular disease risk factors in older adults with type 2 diabetes mellitus: data from the Adult Diabetes Control and Management.2型糖尿病老年患者的血糖及其他心血管疾病危险因素控制:来自成人糖尿病控制与管理的数据
Geriatr Gerontol Int. 2014 Jan;14(1):130-7. doi: 10.1111/ggi.12070. Epub 2013 Apr 15.

引用本文的文献

1
Inequities in atherosclerotic cardiovascular disease prevention.动脉粥样硬化性心血管疾病预防中的不平等现象。
Prog Cardiovasc Dis. 2024 May-Jun;84:43-50. doi: 10.1016/j.pcad.2024.05.002. Epub 2024 May 9.
2
Gaps and Disparities in Primary Prevention Statin Prescription During Outpatient Care.初级预防他汀类药物处方在门诊护理中的差距和差异。
Am J Cardiol. 2021 Dec 15;161:36-41. doi: 10.1016/j.amjcard.2021.08.070.
3
Impact of Race and Location of Residence on Statin Treatment Among Veterans With Type 2 Diabetes Mellitus.种族和居住地点对 2 型糖尿病退伍军人他汀类药物治疗的影响。
Am J Cardiol. 2020 May 15;125(10):1492-1499. doi: 10.1016/j.amjcard.2020.02.027. Epub 2020 Mar 5.
4
Racial-Geographic Disparity in Lipid Management in Veterans with Type 2 Diabetes: A 10-Year Retrospective Cohort Study.2型糖尿病退伍军人血脂管理中的种族地理差异:一项10年回顾性队列研究
Health Equity. 2019 Sep 23;3(1):472-479. doi: 10.1089/heq.2019.0071. eCollection 2019.
5
Vulnerabilities to Health Disparities and Statin Use in the REGARDS (Reasons for Geographic and Racial Differences in Stroke) Study.REGARDS 研究(地理和种族差异导致中风的原因)中存在的健康差异和他汀类药物使用的脆弱性。
J Am Heart Assoc. 2017 Aug 28;6(9):e005449. doi: 10.1161/JAHA.116.005449.
6
Implications of American College of Cardiology/American Heart Association (ACC/AHA) Cholesterol Guidelines on Statin Underutilization for Prevention of Cardiovascular Disease in Diabetes Mellitus Among Several US Networks of Community Health Centers.美国心脏病学会/美国心脏协会(ACC/AHA)胆固醇指南对几种美国社区卫生中心网络中糖尿病患者心血管疾病预防中他汀类药物未充分利用的影响。
J Am Heart Assoc. 2017 Jul 3;6(7):e005627. doi: 10.1161/JAHA.117.005627.
7
Race-Sex Differences in Statin Use and Low-Density Lipoprotein Cholesterol Control Among People With Diabetes Mellitus in the Reasons for Geographic and Racial Differences in Stroke Study.在“中风地理和种族差异原因研究”中糖尿病患者他汀类药物使用及低密度脂蛋白胆固醇控制方面的种族-性别差异
J Am Heart Assoc. 2017 May 10;6(5):e004264. doi: 10.1161/JAHA.116.004264.
8
Race-sex differences in the management of hyperlipidemia: the REasons for Geographic and Racial Differences in Stroke study.高脂血症管理中的种族性别差异:中风地理和种族差异原因研究
Am J Prev Med. 2015 May;48(5):520-7. doi: 10.1016/j.amepre.2014.10.025.
9
Racial differences in the prevalence of severe aortic stenosis.重度主动脉瓣狭窄患病率的种族差异。
J Am Heart Assoc. 2014 May 28;3(3):e000879. doi: 10.1161/JAHA.114.000879.
10
Racial disparities in lipid control in patients with diabetes.糖尿病患者的血脂控制存在种族差异。
Am J Manag Care. 2012 Jun;18(6):303-11.