Safford Monika, Eaton Laura, Hawley Gerald, Brimacombe Michael, Rajan Mangala, Li Huiling, Pogach Leonard
New Jersey Veterans Health Administration Healthcare System, East Orange, NJ, USA.
Arch Intern Med. 2003 Apr 28;163(8):922-8. doi: 10.1001/archinte.163.8.922.
People with diabetes are at high risk for cardiovascular events regardless of known heart disease. Physicians may underrecognize the excess cardiovascular risk conferred by diabetes alone, without a recent cardiovascular event. Other disparities in the receipt of lipid-lowering medications (LLMs) may exist.
We studied veterans with diabetes in fiscal years 1998 and 1999 cross-sectionally. We used administrative data (demographic information, International Classification of Diseases, Ninth Revision [ICD-9] codes, utilization information, medications, and laboratory tests) to evaluate associations between use of LLMs and age, ethnicity, sex, marital status, Charlson Index, heart disease ICD-9 codes, oral agents and insulin, hospitalization status, and low-density lipoprotein cholesterol levels. We constructed separate logistic regression models to evaluate associations between low-density lipoprotein cholesterol and similar predictor variables.
Odds ratios were similar in both years. For fiscal year 1999, patients without recent ICD-9 codes in their administrative data indicating heart disease were 0.35 times less likely to be given LLMs than those with such codes. Individuals older than 75 years were 0.65 times less likely to be given LLMs than those younger than 65 years. African Americans were 0.72 times less likely than whites to be given LLMs. In fiscal years 1999 and 1998, 27% and 36% of individuals given LLMs had low-density lipoprotein cholesterol levels higher than 130 mg/dL (3.37 mmol/L).
Veterans with diabetes but no recently coded heart disease, older individuals, and African Americans could benefit from programs targeted to introduce LLMs. Up to one third of individuals given LLMs remained above the target level of 130 mg/dL for low-density lipoprotein cholesterol.
无论是否患有已知的心脏病,糖尿病患者发生心血管事件的风险都很高。医生可能未充分认识到仅由糖尿病导致的额外心血管风险,而患者近期又未发生心血管事件。在接受降脂药物(LLMs)治疗方面可能还存在其他差异。
我们对1998财年和1999财年的糖尿病退伍军人进行了横断面研究。我们使用行政数据(人口统计学信息、国际疾病分类第九版[ICD - 9]编码、使用信息、药物和实验室检查结果)来评估降脂药物的使用与年龄、种族、性别、婚姻状况、查尔森指数、心脏病ICD - 9编码、口服药物和胰岛素、住院状态以及低密度脂蛋白胆固醇水平之间的关联。我们构建了单独的逻辑回归模型来评估低密度脂蛋白胆固醇与类似预测变量之间的关联。
两年的比值比相似。对于1999财年,行政数据中没有近期ICD - 9编码表明患有心脏病的患者接受降脂药物治疗的可能性比有此类编码的患者低0.35倍。75岁以上的个体接受降脂药物治疗的可能性比65岁以下的个体低0.65倍。非裔美国人接受降脂药物治疗的可能性比白人低0.72倍。在1999财年和1998财年,接受降脂药物治疗的个体中分别有27%和36%的低密度脂蛋白胆固醇水平高于130 mg/dL(3.37 mmol/L)。
患有糖尿病但近期无心脏病编码的退伍军人、老年人和非裔美国人可能会从旨在引入降脂药物的项目中受益。接受降脂药物治疗的个体中,高达三分之一的人的低密度脂蛋白胆固醇水平仍高于130 mg/dL的目标水平。