Davis Richard J, Doerflinger Alicia, McCurley Melissa, Swithers Susan E
Department of Psychological Sciences, Purdue University, West Lafayette, IN 47907-1364, USA.
Nutr Neurosci. 2003 Apr;6(2):81-91. doi: 10.1080/1028415031000084463.
In adult rats, the rate of gastric emptying is modulated by properties of the diet, including its caloric content and osmotic properties. In developing pups, there is little known about the modulation of gastric emptying, despite evidence that volume of gastric contents may play a significant role in modulating intake in young rats. The present experiments examined gastric emptying of oral infusions of corn oil emulsions or glucose solutions in pups aged 6 or 15 days of age and their effects on independent ingestion. The results demonstrated that pups as young as 6 days of age modulate the rate of gastric emptying in response to changes in the concentration of a corn oil or glucose diet. However, oral infusions of corn oil emulsions failed to produce differences in subsequent intake of a milk diet, while oral infusions of a glucose diet did suppress subsequent intake. Taken together, the results support different ontogenetic courses for the development of mechanisms modulating gastric emptying of lipid versus carbohydrate diets, and suggest that gastric fill plays a limited role in modulation of intake in young pups.
在成年大鼠中，胃排空速率受饮食特性调节，包括热量含量和渗透特性。在发育中的幼崽中，尽管有证据表明胃内容物体积可能在调节幼鼠摄入量方面发挥重要作用，但关于胃排空的调节却知之甚少。本实验研究了6日龄或15日龄幼崽口服玉米油乳剂或葡萄糖溶液后的胃排空情况及其对自主摄食的影响。结果表明，年仅6日龄的幼崽会根据玉米油或葡萄糖饮食浓度的变化来调节胃排空速率。然而，口服玉米油乳剂并未导致后续牛奶饮食摄入量出现差异，而口服葡萄糖饮食则抑制了后续摄入量。综上所述，这些结果支持了调节脂质与碳水化合物饮食胃排空的机制在发育过程中存在不同的个体发生过程，并表明胃充盈在幼崽摄入量调节中作用有限。
