Horn C C, Tordoff M G, Friedman M I
Department of Psychology, Kansas State University, Manhattan 66506, USA.
Am J Physiol. 1996 Apr;270(4 Pt 2):R761-5. doi: 10.1152/ajpregu.1996.270.4.R761.
Administration of fat directly into the gastrointestinal tract of rats produces a rapid and often substantial reduction of feeding behavior. This contrasts with the normal consumption of a fat meal, which produces little change in subsequent food intake. To determine whether procedural differences account for this discrepancy, we examined the satiating effect of ingested fat on food intake of rats maintained under feeding conditions similar to those employed in studies involving gastrointestinal delivery of fat (i.e., food deprivation, liquid diet). Ingestion of approximately 1.5 ml corn oil had no effect on subsequent liquid diet intake until 90 min after oil ingestion. When rats ingested oil 4 h before access to the liquid diet, to allow time for additional gastrointestinal clearance, liquid diet intake was reduced by 13% in the first 30 min of access. These findings indicate that ingested fat decreases short-term intake slightly, but only if time is allowed for postabsorptive delivery. The results question the physiological significance of the marked suppression of food intake observed in response to administration of fat directly into the gastrointestinal tract.
将脂肪直接注入大鼠胃肠道会迅速且常常显著减少摄食行为。这与正常食用脂肪餐形成对比，正常食用脂肪餐对随后的食物摄入量几乎没有影响。为了确定操作差异是否导致了这种差异，我们研究了摄入脂肪对处于类似于涉及胃肠道脂肪输送研究中所采用的摄食条件下（即食物剥夺、流食）的大鼠食物摄入量的饱腹感影响。摄入约1.5毫升玉米油对随后的流食摄入量没有影响，直到摄入油后90分钟。当大鼠在获得流食前4小时摄入油，以便有时间进行额外的胃肠道清除时，在获得流食的前30分钟内，流食摄入量减少了13%。这些发现表明，摄入的脂肪会略微减少短期摄入量，但前提是要有时间进行吸收后输送。结果对直接将脂肪注入胃肠道后观察到的明显食物摄入量抑制的生理意义提出了质疑。
