Cheng Kang, Zou Chang-Hua
Biomed Sci Instrum. 2003;39:77-82.
In this study, we propose new concepts of Active Potential Energy Well, Specificity and Non-Specificity of the wells. We perform these concepts to establish a 3-D physical model and to elucidate how a complete functional ribosome traps an aminoacyl tRNA, and how it moves along the mRNA template in the elongation of protein synthesis. In our model, we first introduce concepts of reduced mass and relative coordinates of a two objects system. Then we simplify a ribosome movement along mRNA in protein synthesis. We also introduce concepts of active objects and active controls in this study. Our model is based on quantum mechanics, thermal dynamics and the published biochemical data.
在本研究中，我们提出了活性势能阱、阱的特异性和非特异性等新概念。我们运用这些概念建立了一个三维物理模型，以阐明完整的功能性核糖体如何捕获氨酰tRNA，以及它在蛋白质合成延伸过程中如何沿着mRNA模板移动。在我们的模型中，我们首先引入了两物体系统的约化质量和相对坐标的概念。然后我们简化了蛋白质合成中核糖体沿mRNA的移动。在本研究中我们还引入了活性物体和活性控制的概念。我们的模型基于量子力学、热动力学以及已发表的生化数据。
