Hein Michael S
USD School of Medicine, USA.
S D J Med. 2003 Apr;56(4):143-7.
Zinc is a ubiquitous element that is essential for normal enzymatic function in multiple metabolic pathways. Chronic excessive zinc ingestion causes severe reversible anemia in humans. In animals, zinc toxicity leads to anemia as well as physiologic and morphologic damage to the pancreas, kidneys, and often, multisystem failure and death. In this case, a young female ingested approximately 2000 mg of zinc gluconate daily for 12 months. She subsequently developed anemia consistent with zinc-induced copper deficiency and severe nephrosis. After cessation of zinc ingestion, her anemia and nephrosis resolved. This case study underscores the importance of an accurate and thorough investigation of nutritional supplements during the history and physical examination. Given the promulgation of zinc for the treatment of skin disorders and the common cold, along with the commercialization of nutritional supplements, unimpeded by regulatory guidelines, it is imperative that primary care physicians be attuned to the potentially dangerous consequences of excessive zinc ingestion.
锌是一种普遍存在的元素，对多种代谢途径中的正常酶功能至关重要。长期过量摄入锌会导致人类严重的可逆性贫血。在动物中，锌中毒会导致贫血以及胰腺、肾脏的生理和形态损伤，常出现多系统衰竭和死亡。在本病例中，一名年轻女性连续12个月每天摄入约2000毫克葡萄糖酸锌。随后她出现了与锌诱导的铜缺乏一致的贫血和严重肾病。停止摄入锌后，她的贫血和肾病得到缓解。本病例研究强调了在病史和体格检查期间对营养补充剂进行准确、全面调查的重要性。鉴于锌被用于治疗皮肤疾病和感冒，以及营养补充剂的商业化，不受监管指南的限制，初级保健医生必须意识到过量摄入锌的潜在危险后果。
