Hoffman H N, Phyliky R L, Fleming C R
Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota.
Gastroenterology. 1988 Feb;94(2):508-12. doi: 10.1016/0016-5085(88)90445-3.
Copper deficiency was found in an adult patient who had received excessive daily oral zinc for 10 mo. The deficiency was characterized by hypochromic-microcytic anemia, leukopenia, and neutropenia. Although initially thought to be caused by iron deficiency, the anemia did not respond to oral or intravenous iron. Cessation of zinc tablets and ingestion of an oral copper preparation daily for 2 mo failed to correct the anemia or leukopenia. It was not until shortly after intravenous administration of a cupric chloride solution during a 5-day period, at a total dose of 10 mg, that serum copper and ceruloplasmin levels increased and the anemia, leukopenia, and neutropenia resolved. These data suggest that the elimination of excess zinc is slow and that, until such elimination occurs, the intestinal absorption of copper is blocked.
在一名成年患者中发现了铜缺乏症，该患者连续10个月每日口服过量锌。这种缺乏症的特征是低色素小细胞性贫血、白细胞减少和中性粒细胞减少。尽管最初认为贫血是由缺铁引起的，但口服或静脉注射铁剂均无效。停用锌片并每日口服铜制剂2个月未能纠正贫血或白细胞减少。直到在5天内静脉注射氯化铜溶液，总剂量为10毫克后不久，血清铜和铜蓝蛋白水平才升高，贫血、白细胞减少和中性粒细胞减少才得以缓解。这些数据表明，过量锌的消除缓慢，在消除之前，肠道对铜的吸收会被阻断。
