Caiazza Nicky C, O'Toole G A
Department of Microbiology and Immunology, Dartmouth Medical School, Hanover, New Hampshire 03755, USA.
J Bacteriol. 2003 May;185(10):3214-7. doi: 10.1128/JB.185.10.3214-3217.2003.
Staphylococcus aureus is a common pathogen associated with nosocomial infections. It can persist in clinical settings and gain increased resistance to antimicrobial agents through biofilm formation. We have found that alpha-toxin, a secreted, multimeric, hemolytic toxin encoded by the hla gene, plays an integral role in biofilm formation. The hla mutant was unable to fully colonize plastic surfaces under both static and flow conditions. Based on microscopy studies, we propose that alpha-hemolysin is required for cell-to-cell interactions during biofilm formation.
金黄色葡萄球菌是一种与医院感染相关的常见病原体。它可在临床环境中持续存在，并通过形成生物膜而增强对抗菌药物的耐药性。我们发现，α毒素是一种由hla基因编码的分泌型多聚体溶血毒素，在生物膜形成中起着不可或缺的作用。hla突变体在静态和流动条件下均无法在塑料表面完全定殖。基于显微镜研究，我们提出，α溶血素是生物膜形成过程中细胞间相互作用所必需的。
