与人类T细胞亚群发生反应的同种抗体。

Alloantibodies that react with subsets of human T cells.

作者信息

van Leeuwen A

机构信息

Department of Immunology, London Hospital Medical College, London, UK.

出版信息

Tissue Antigens. 1979 Nov;14(5):437-43. doi: 10.1111/j.1399-0039.1979.tb00872.x.

DOI:10.1111/j.1399-0039.1979.tb00872.x

PMID:12731575

Abstract

Using the two color fluorescence (TCF) method, alloantibodies against subsets of T cells could be detected in sera from pregnant women with strong HLA antibodies. To preclude interference of these HLA antibodies with the recognition of the T cell antibodies, serum donors were selected which were HLA-Al, -B8, -DRw3. Their sera were tested on a panel of individuals homozygous for HLA-Al, -B8, -DRw3. By enriching peripheral mononuclear blood lymphocytes for Tgamma cells it could be shown that some of the sera reacted mainly with Tgamma and others with Tmu lymphocytes, while some sera reacted with both.

摘要

使用双色荧光（TCF）方法，可以在具有强HLA抗体的孕妇血清中检测到针对T细胞亚群的同种抗体。为了排除这些HLA抗体对T细胞抗体识别的干扰，选择了HLA-A1、-B8、-DRw3的血清供体。在一组HLA-A1、-B8、-DRw3纯合个体上检测他们的血清。通过富集外周血单个核淋巴细胞中的Tγ细胞，可以发现一些血清主要与Tγ细胞反应，另一些与Tμ淋巴细胞反应，而有些血清则与两者都反应。