Calgüner E, Gözil R, Erdoğan D, Kurt I, Keskil S, Elmas C, Sabuncuoğlu H
Department of Anatomy, Gazi University School of Medicine, Besevler, Ankara, Turkey.
Anat Histol Embryol. 2003 Feb;32(1):54-9. doi: 10.1046/j.1439-0264.2003.00439.x.
Destruction and denervation atrophy in skeletal muscles caused by the injection of local anaesthetics was investigated by injecting lidocaine or bupivacaine around the rabbit facial nerve to produce facial paralysis. Animals were then sacrificed at 2, 4, 6, and 8 weeks post-injection, and changes in mimic muscle tissue were assessed at each stage by light microscopy and electron microscopy. Atrophic changes were observed at 2-6 weeks after injection, and regeneration started at 6-8 weeks. Compared to bupivacaine, lidocaine caused more dramatic atrophic changes and was associated with slower muscle regeneration.
通过在兔面神经周围注射利多卡因或布比卡因以导致面部麻痹，研究局部麻醉剂注射引起的骨骼肌破坏和去神经萎缩。然后在注射后2、4、6和8周处死动物，并在每个阶段通过光学显微镜和电子显微镜评估表情肌组织的变化。注射后2至6周观察到萎缩变化，6至8周开始再生。与布比卡因相比，利多卡因引起更显著的萎缩变化，且与肌肉再生较慢有关。
