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国际命名与诊断标准协调（INHAND）：兔的非增殖性和增殖性病变

International Harmonization of Nomenclature and Diagnostic Criteria (INHAND): Nonproliferative and Proliferative Lesions of the Rabbit.

作者信息

Bradley Alys E, Wancket Lyn Miller, Rinke Matthias, Gruebbel Margarita M, Saladino Brett H, Schafer Kenneth, Katsuta Osamu, Garcia Begonya, Chanut Franck, Hughes Katherine, Nelson Keith, Himmel Lauren, McInnes Elizabeth, Schucker Adrienne, Uchida Kazuyuki

机构信息

Charles River Laboratories Edinburgh Ltd, Tranent, Scotland, UK.

Charles River Laboratories, Durham, NC, USA.

出版信息

J Toxicol Pathol. 2021;34(3 Suppl):183S-292S. doi: 10.1293/tox.34.183S. Epub 2021 Sep 28.

DOI:10.1293/tox.34.183S
PMID:34712007
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8544166/
Abstract

The INHAND (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions Project (www.toxpath.org/inhand.asp) is a joint initiative of the Societies of Toxicologic Pathology from Europe (ESTP), Great Britain (BSTP), Japan (JSTP) and North America (STP) to develop an internationally accepted nomenclature for proliferative and non-proliferative lesions in laboratory animals. The purpose of this publication is to provide a standardized nomenclature for classifying microscopic lesions observed in most tissues and organs from the laboratory rabbit used in nonclinical safety studies. Some of the lesions are illustrated by color photomicrographs. The standardized nomenclature presented in this document is also available electronically on the internet (http://www.goreni.org/). Sources of material included histopathology databases from government, academia, and industrial laboratories throughout the world. Content includes spontaneous lesions as well as lesions induced by exposure to test materials. Relevant infectious and parasitic lesions are included as well. A widely accepted and utilized international harmonization of nomenclature for lesions in laboratory animals will provide a common language among regulatory and scientific research organizations in different countries and increase and enrich international exchanges of information among toxicologists and pathologists.

摘要

国际实验动物病理损伤命名与诊断标准协调项目（INHAND）（www.toxpath.org/inhand.asp）是欧洲毒理病理学会（ESTP）、英国毒理病理学会（BSTP）、日本毒理病理学会（JSTP）和北美毒理病理学会（STP）的联合倡议，旨在为实验动物的增殖性和非增殖性损伤制定国际认可的命名法。本出版物的目的是为非临床安全性研究中使用的实验兔的大多数组织和器官中观察到的微观损伤分类提供标准化命名法。部分损伤以彩色显微照片展示。本文件中提出的标准化命名法也可在互联网上以电子形式获取（http://www.goreni.org/）。材料来源包括世界各地政府、学术界和工业实验室的组织病理学数据库。内容包括自发损伤以及接触试验材料引起的损伤。相关的感染性和寄生虫性损伤也包括在内。广泛接受和使用的实验动物损伤命名国际协调将为不同国家的监管和科研组织提供一种通用语言，并增加和丰富毒理学家和病理学家之间的国际信息交流。

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5
Encephalitozoon cuniculi infection in farmed rabbits in Egypt.埃及养殖兔的兔脑炎原虫感染。
Acta Vet Scand. 2020 Feb 22;62(1):11. doi: 10.1186/s13028-020-0509-6.
6
Predominance of Granular Cell Tumours among Testicular Tumours of Rabbits (Oryctolagus cuniculi f. dom.).家兔（穴兔家兔变种）睾丸肿瘤中颗粒细胞瘤占主导地位。
J Comp Pathol. 2019 Nov;173:24-29. doi: 10.1016/j.jcpa.2019.09.012. Epub 2019 Nov 1.
7
Atlas of Normal Microanatomy, Procedural and Processing Artifacts, Common Background Findings, and Neurotoxic Lesions in the Peripheral Nervous System of Laboratory Animals.《实验室动物周围神经系统正常微观解剖、操作与处理伪影、常见背景发现和神经毒性病变图谱》。
Toxicol Pathol. 2020 Jan;48(1):105-131. doi: 10.1177/0192623319867322. Epub 2019 Aug 19.
8
Accessory Genital Glands in the New Zealand White Rabbit: A Morphometrical and Histological Study.新西兰白兔的附属生殖腺：一项形态计量学与组织学研究。
J Vet Res. 2019 Jun 12;63(2):251-257. doi: 10.2478/jvetres-2019-0028. eCollection 2019 Jun.
9
Interstitial Adipocytes in the Beagle Dog and New Zealand White Rabbit Choroid Plexus.
Toxicol Pathol. 2019 Jun;47(4):553-555. doi: 10.1177/0192623319839916. Epub 2019 Apr 15.
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Pathological Features of Corneal Phospholipidosis in Juvenile White Rabbits Induced by Ocular Instillation of Chloroquine or Amiodarone.经眼内滴注氯喹或胺碘酮诱导的幼年白兔角膜磷脂沉积症的病理特征
Toxicol Pathol. 2019 Jan;47(1):26-34. doi: 10.1177/0192623318809000. Epub 2018 Oct 29.