Landa García J I, Carabias Hernández A, Rodríguez Dapena S, Alcalde Escribano J, Ortega Medina L, Balibrea Cantero J L
General and Digestive System Surgery Department B, H.U. La Paz, Madrid, Spain.
Rev Esp Enferm Dig. 2002 Dec;94(12):737-44.
The use of vagotomy is classically based on its inhibiting effects on acid secretion. Vagotomy induces both cellular and endocrine changes that may be involved in protective actions. Our aim was to study morphologic changes induced by vagotomy on the gastric mucosa and their relation to stress protection in the short, medium and long term.
An immobilization and cold stress model was used with 80 Wistar rats divided into two groups--control (with and without stress) and vagotomy (at 7, 30 and 120 days). Changes induced in the gastric mucosa by stress were studied with and without vagotomy, as well as relationship between these changes and the intended protective action.
Bleeding showed a very significant relation to stress (p < 0.0001). Bleeding incidence exhibited a significant difference between vagotomised and non-vagotomised rats (p < 0.0001) in the short, medium and long term (vagotomy was protective against stress). Regeneration signs related significantly to vagotomy (p < 0.0001) but not stress (p = 0.208). However, no significant relationship was found between the protective action and the presence of regeneration signs (p = 1).
Vagotomy has tropic effects on the gastric mucosa and is protective against stress. This protective action is maintained in the short, medium and long term. However, these changes are not sufficient to explain protection. An adaptation phenomenon mediated by hormonal and peptidic factors may be involved in this action.
迷走神经切断术的应用传统上基于其对胃酸分泌的抑制作用。迷走神经切断术会引发细胞和内分泌变化，这些变化可能参与保护作用。我们的目的是研究迷走神经切断术在短期、中期和长期对胃黏膜诱导的形态学变化及其与应激保护的关系。
使用固定和冷应激模型，将80只Wistar大鼠分为两组——对照组（有应激和无应激）和迷走神经切断术组（术后7天、30天和120天）。研究了有无迷走神经切断术时应激对胃黏膜诱导的变化，以及这些变化与预期保护作用之间的关系。
出血与应激有非常显著的关系（p < 0.0001）。在短期、中期和长期，迷走神经切断术大鼠和未切断迷走神经大鼠的出血发生率有显著差异（p < 0.0001）（迷走神经切断术对应激有保护作用）。再生迹象与迷走神经切断术有显著关系（p < 0.0001），但与应激无关（p = 0.208）。然而，在保护作用与再生迹象之间未发现显著关系（p = 1）。
迷走神经切断术对胃黏膜有促生长作用，且对应激有保护作用。这种保护作用在短期、中期和长期均得以维持。然而，这些变化不足以解释其保护作用。由激素和肽类因子介导的适应现象可能参与了这一作用。
