Khanna Manish, Fortier-Riberdy Geneviève, Dinehart Scott M, Smoller Bruce
Department of Dermatology, University of Arkansas for Medical Sciences, Little Rock, USA.
J Am Acad Dermatol. 2003 May;48(5):721-6. doi: 10.1067/mjd.2003.85.
There are numerous histopathologic features related to prognosis in cutaneous squamous cell carcinoma (CSCC). We hypothesize that there is no uniform approach toward the reporting of these features. This may be related to differing opinions on their prognostic use.
A written survey concerning the microscopic evaluation of CSCC was sent to 120 dermatopathologists in the United States and Canada. Respondents were asked whether they comment on specific microscopic features of CSCC, and whether they believe that each specific feature can predict prognosis.
The response rate was 78%. Histologic type, and the presence of perineural or vascular/lymphatic invasion, is reported by most dermatopathologists (90%, 96%, and 95%, respectively). These features are also thought to predict prognosis by the majority of respondents. Only 54% report histologic grade, and 49% think grade predicts prognosis. Depth is reported anatomically by 63%, but by only 8% in actual millimeters of invasion. However, 55% think tumor depth predicts prognosis. A total of 43% report the presence of an associated actinic keratosis, although very few (16%) think it predicts prognosis. Very few comment on the presence of inflammation.
Histopathologic reporting of CSCC is not uniform among dermatopathologists. Also, there appears to be differing opinions on the use of certain histopathologic features for predicting prognosis.
皮肤鳞状细胞癌（CSCC）中有许多与预后相关的组织病理学特征。我们推测，对于这些特征的报告没有统一的方法。这可能与对其预后用途的不同观点有关。
向美国和加拿大的120名皮肤病理学家发送了一份关于CSCC显微镜评估的书面调查问卷。受访者被问及是否会对CSCC的特定显微镜特征发表评论，以及他们是否认为每个特定特征都能预测预后。
回复率为78%。大多数皮肤病理学家（分别为90%、96%和95%）报告了组织学类型以及神经周围或血管/淋巴管浸润的存在情况。大多数受访者也认为这些特征可以预测预后。只有54%的人报告组织学分级，49%的人认为分级可以预测预后。63%的人按解剖学方式报告深度，但只有8%的人报告实际浸润毫米数。然而，55%的人认为肿瘤深度可以预测预后。共有43%的人报告存在相关的光化性角化病，尽管很少有人（16%）认为它可以预测预后。很少有人对炎症的存在发表评论。
皮肤病理学家对CSCC的组织病理学报告并不统一。此外，对于某些组织病理学特征在预测预后方面的应用似乎存在不同观点。
