Parekh Vishwas, Seykora John T
Department of Pathology, City of Hope Comprehensive Cancer Center, 1500 East Duarte Road, Duarte, CA, 91010, USA.
Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Room 1011 BRB II/III, 421 Curie Boulevard, Philadelphia, PA 19104, USA.
Clin Lab Med. 2017 Sep;37(3):503-525. doi: 10.1016/j.cll.2017.06.003.
Cutaneous squamous cell carcinoma (cSCC) is a malignant neoplasm of the skin characterized by an aberrant proliferation of keratinocytes. Cutaneous SCC is the second most common malignancy globally, and usually arises in the chronically sun-damaged skin of elderly white individuals. From a pathologist's perspective, it is important to differentiate cSCC from the benign and reactive squamoproliferative lesions and identify the high-risk features associated with aggressive tumor behavior. In this article, we provide an up-to-date overview of cSCC along with its precursor lesions and important histologic variants, with a particular emphasis on the histopathologic features and molecular pathogenesis.
皮肤鳞状细胞癌（cSCC）是一种皮肤恶性肿瘤，其特征为角质形成细胞异常增殖。皮肤鳞状细胞癌是全球第二常见的恶性肿瘤，通常发生于老年白人长期受阳光损伤的皮肤。从病理学家的角度来看，将皮肤鳞状细胞癌与良性和反应性鳞状上皮增生性病变区分开来，并识别与侵袭性肿瘤行为相关的高危特征非常重要。在本文中，我们提供了皮肤鳞状细胞癌及其前驱病变和重要组织学变体的最新概述，特别强调了组织病理学特征和分子发病机制。
