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类胶原片段：骨佩吉特病患者尿液中的排泄情况

Collagen-like fragments: excretion in urine of patients with Paget's disease of bone.

作者信息

Krane S M, Muñoz A J, Harris E D

出版信息

Science. 1967 Aug 11;157(3789):713-6. doi: 10.1126/science.157.3789.713.

DOI:10.1126/science.157.3789.713
PMID:6028049
Abstract

Patients with Paget's disease of bone excrete, in the urine, polypeptides that have amino acid composition and other properties resembling those of fragments of collagen. The pattern of isotope incorporation in vivo suggests that these fragments are derived from collagen that has been synthesized and rapidly degraded, or that they are rapidly synthesized but not incorporated into tropocollagen molecules.

摘要

患有佩吉特骨病的患者尿液中会排出一些多肽，这些多肽的氨基酸组成和其他特性与胶原蛋白片段相似。体内同位素掺入模式表明，这些片段源自已合成并迅速降解的胶原蛋白，或者它们是迅速合成但未掺入原胶原蛋白分子中的。

相似文献

1
Collagen-like fragments: excretion in urine of patients with Paget's disease of bone.类胶原片段：骨佩吉特病患者尿液中的排泄情况
Science. 1967 Aug 11;157(3789):713-6. doi: 10.1126/science.157.3789.713.
2
Urinary polypeptides related to collagen synthesis.与胶原蛋白合成相关的尿多肽。
J Clin Invest. 1970 Apr;49(4):716-29. doi: 10.1172/JCI106284.
3
Polymorphism of urinary 4-hydroxyproline-containing polypeptides.含4-羟基脯氨酸的尿多肽的多态性
J Chromatogr. 1981 Sep 11;225(1):55-63. doi: 10.1016/s0378-4347(00)80243-1.
4
[Chromatographic analysis of urinary amino acids in Paget's disease. I : Biochemical study. Isolation and amino acid composition of a urinary peptide specific to this bone disease].佩吉特病患者尿氨基酸的色谱分析。I：生化研究。该骨病特异性尿肽的分离及氨基酸组成
Rev Rhum Mal Osteoartic. 1976 Apr;43(4):249-53.
5
Urinary excretion of glycosaminoglycans and hydroxyproline in Paget's disease of bone, compared with neoplastic invasion of bone.与骨肿瘤浸润相比，骨Paget病中糖胺聚糖和羟脯氨酸的尿排泄情况。
J Clin Pathol. 1981 Oct;34(10):1097-101. doi: 10.1136/jcp.34.10.1097.
6
Urinary excretion of hydroxyproline, hydroxylysine and hydroxylysine glycosides by patients with Paget's disease of bone and carcinoma with metastases in bone.患有骨Paget病及骨转移癌的患者尿中羟脯氨酸、羟赖氨酸及羟赖氨酸糖苷的排泄情况。
Clin Chim Acta. 1979 Mar 15;92(3):373-9. doi: 10.1016/0009-8981(79)90216-x.
7
[Chromatographic analysis of urinary amino acids in Paget's disease. II : clinical study].佩吉特病患者尿氨基酸的色谱分析。II：临床研究
Rev Rhum Mal Osteoartic. 1976 Apr;43(4):255-8.
8
Measurement of urinary excretion of nonisomerized and beta-isomerized forms of type I collagen breakdown products to monitor the effects of the bisphosphonate zoledronate in Paget's disease.测量I型胶原降解产物的非异构化和β-异构化形式的尿排泄量，以监测双膦酸盐唑来膦酸在佩吉特病中的作用。
Arthritis Rheum. 1998 Feb;41(2):354-60. doi: 10.1002/1529-0131(199802)41:2<354::AID-ART20>3.0.CO;2-5.
9
Determination of hydroxyproline polypeptides in urine and blood serum by gel filtration.通过凝胶过滤法测定尿液和血清中的羟脯氨酸多肽。
Clin Chim Acta. 1975 Jul 23;62(2):277-86. doi: 10.1016/0009-8981(75)90237-5.
10
Prediction of the outcome of treatment of Paget's disease of bone with bisphosphonates from short-term changes in the rate of bone resorption.
J Clin Endocrinol Metab. 1996 Nov;81(11):3993-7. doi: 10.1210/jcem.81.11.8923849.

引用本文的文献

1
The "spindle-shaped" body in fibroblasts: intracellular collagen fibrils.成纤维细胞中的“纺锤形”小体：细胞内胶原纤维。
J Anat. 1981 Mar;132(Pt 2):157-66.
2
Bone turnover in Paget's disease: biochemical and kinetic measurements during salmon calcitonin therapy.佩吉特病中的骨转换：鲑鱼降钙素治疗期间的生化及动力学测量
Calcif Tissue Int. 1981;33(5):471-6. doi: 10.1007/BF02409476.
3
Synovial fluid beta 2 microglobulin and hydroxyproline fractions in rheumatoid arthritis and nonautoimmune arthropathies.类风湿关节炎和非自身免疫性关节病中滑液β2微球蛋白和羟脯氨酸组分
Ann Rheum Dis. 1980 Jun;39(3):207-16. doi: 10.1136/ard.39.3.207.
4
Acute effects of removal of parathyroid adenoma on plasma and urinary hydroxyproline levels.甲状旁腺腺瘤切除对血浆和尿羟脯氨酸水平的急性影响。
J Endocrinol Invest. 1984 Dec;7(6):563-8. doi: 10.1007/BF03349487.
5
Recent advances in the unerstanding and management of metabolic bone disease.代谢性骨病的认识与管理方面的最新进展。
Proc R Soc Med. 1970 Sep;63(9):931-4. doi: 10.1177/003591577006300930.
6
Urinary polypeptides related to collagen synthesis.与胶原蛋白合成相关的尿多肽。
J Clin Invest. 1970 Apr;49(4):716-29. doi: 10.1172/JCI106284.
7
Medical staff conference. Paget disease of bone.医务人员会议。骨佩吉特病。
West J Med. 1978 Sep;129(3):210-24.