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Combinatorial chemistry as a new approach in antiparasitic drug discovery.

作者信息

Link Andreas

机构信息

Philipps-Universität Marburg, Marbacher Weg 6, 35037 Marburg, Germany.

出版信息

Parasitol Res. 2003 Jun;90 Suppl 2:S86-90. doi: 10.1007/s00436-002-0772-7. Epub 2003 May 7.

DOI:10.1007/s00436-002-0772-7
PMID:12734752
Abstract

Key challenges in antiparasitic drug discovery are target selection and identification of appropriate small molecules as potential ligands for these targets. Novel tools and techniques continue to be developed to address both of these problems. This report focuses on the application of a suite of technologies summarized as combinatorial chemistry. Recent success using these technologies is explored, reasons for frequent failure are given and discussed.

摘要

相似文献

1
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2
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本文引用的文献

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A common mechanism underlying promiscuous inhibitors from virtual and high-throughput screening.虚拟筛选和高通量筛选中混杂抑制剂的共同潜在机制。
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Tyrosylprotein sulfotransferase inhibitors generated by combinatorial target-guided ligand assembly.
通过组合靶标导向配体组装产生的酪氨酰蛋白磺基转移酶抑制剂
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Identification of potent and selective mechanism-based inhibitors of the cysteine protease cruzain using solid-phase parallel synthesis.使用固相平行合成法鉴定半胱氨酸蛋白酶克鲁兹蛋白酶的强效和选择性基于机制的抑制剂。
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Dynamic combinatorial chemistry.动态组合化学
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Enzymatically cleavable linker groups in polymer-supported synthesis.
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Development of a virtual screening method for identification of "frequent hitters" in compound libraries.一种用于识别化合物库中“频繁命中物”的虚拟筛选方法的开发。
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Improving an antitrypanosomal lead applying nucleophilic substitution on a safety catch linker.
Bioorg Med Chem. 2002 Jan;10(1):159-65. doi: 10.1016/s0968-0896(01)00253-x.
9
Virtual screening of combinatorial libraries across a gene family: in search of inhibitors of Giardia lamblia guanine phosphoribosyltransferase.针对一个基因家族的组合文库进行虚拟筛选：寻找贾第虫鸟嘌呤磷酸核糖基转移酶的抑制剂。
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10
Adenosine analogues as selective inhibitors of glyceraldehyde-3-phosphate dehydrogenase of Trypanosomatidae via structure-based drug design.通过基于结构的药物设计，腺苷类似物作为锥虫科3-磷酸甘油醛脱氢酶的选择性抑制剂。
J Med Chem. 2001 Jun 21;44(13):2080-93. doi: 10.1021/jm000472o.