Byström J
Scand J Urol Nephrol. 1976;10(1):21-5. doi: 10.3109/00365597609179649.
Eighteen patients with plastic induration of the penis were treated with procarbazine, a cytotoxic agent. Ten patients experienced a good to excellent result; 7 patients no improvement and in one patient treatment had to be prematurely withdrawn because of gastro-intestinal side-effects. No other serious side-effects occurred in the present investigation. Patients with impaired erection, previous gastric surgery and alcoholics are deemed less suitable for this form of therapy. It can be recommended to other patients in otherwise good condition and is especially suitable when diffuse fibrosis is present or when cavernosography indicates deep infiltration of the disease into the intercavernous septum. Selection can be made from those patients who show no tendency to spontaneous remission or those unsuitable for or unresponsive to other therapeutic measures.
18例阴茎海绵体硬结症患者接受了细胞毒性药物丙卡巴肼治疗。10例患者疗效良好至极佳；7例患者无改善，1例患者因胃肠道副作用而不得不提前停药。本次研究未出现其他严重副作用。勃起功能受损、曾接受胃部手术的患者以及酗酒者被认为不太适合这种治疗方式。对于其他情况良好的患者可以推荐使用，尤其适用于存在弥漫性纤维化或海绵体造影显示疾病深入海绵体间隔浸润的情况。可以从那些没有自发缓解倾向、不适合其他治疗措施或对其他治疗措施无反应的患者中进行选择。
