Fernández I, Castellano G, de Salamanca R E, Colina F, Gómez de la Cámara A, Morán M J, Muñoz R, Solís-Herruzo J A
Dept. of Gastroenterology, Unit for the Study of Porphyrias, Pathology and Clinical Epidemiology, Hospital Universitario '12 de Octubre', Madrid, Spain.
Scand J Gastroenterol. 2003 Mar;38(3):314-9.
Porphyria cutanea tarda (PCT) is sometimes associated with hepatitis C virus chronic infection. The aim of this study was to describe the effect of interferon alfa (IFN-alpha) in the treatment of patients with chronic hepatitis C and PCT.
We treated a total of 66 patients with chronic hepatitis C with IFN-alpha 2b (5 MU t.i.w.) for 12 months. Twenty-two of these patients suffered from PCT as well. These patients differed from patients without PCT in that they were men, past history of alcohol abuse and HFE gene mutations were more common and the source of infection was almost always unknown.
Sustained virologic response was obtained in 19.7% of the 66 treated patients, 27.3% in the non-PCT group and 4.5% in the PCT group (P < 0.05). This difference could not be ascribed to the difference in sex of patients, history of alcohol abuse, HCV genotype or iron status.
Multivariate logistic regression analysis revealed that PCT is independently and significantly associated with non-sustained response to IFNalpha therapy. In conclusion, patients with chronic hepatitis C and PCT rarely responded to IFNalpha treatment.
迟发性皮肤卟啉症（PCT）有时与丙型肝炎病毒慢性感染相关。本研究的目的是描述干扰素α（IFN-α）治疗慢性丙型肝炎合并PCT患者的效果。
我们总共用IFN-α 2b（5 MU，每周3次）治疗了66例慢性丙型肝炎患者，疗程为12个月。其中22例患者也患有PCT。这些患者与无PCT的患者不同之处在于，他们多为男性，有酗酒史和HFE基因突变更为常见，且感染源几乎总是不明。
66例接受治疗的患者中，19.7%获得持续病毒学应答，非PCT组为27.3%，PCT组为4.5%（P<0.05）。这种差异不能归因于患者性别、酗酒史、HCV基因型或铁状态的差异。
多因素逻辑回归分析显示，PCT与对IFNα治疗无持续应答独立且显著相关。总之，慢性丙型肝炎合并PCT的患者对IFNα治疗很少有反应。
