Chaudry I H, Sayeed M M, Baue A E
Surgery. 1976 Jun;79(6):666-8.
Hemorrhagic shock was produced in conscious rats by cannulating the subclavian arteries and bleeding the animals to a mean arterial pressure of 40 mm. Hg, which was maintained for one hour (early shock) or 2 hours (late shock). Analysis of diaphragm (working muscle) showed that there was a significant decrease in adenosine triphosphate (ATP), adenosine diphosphate (ADP), and creatine phosphate levels beginning with early shock, whereas in soleus muscle (resting muscle) these changes were not observed until late shock. Decreases in adenine nucleotides of diaphragm were less than in working organs such as liver and kidney in early shock. This suggests that the extent of decrease in adenine nucleotides during shock may be related to the metabolic activity of the organ.
通过插入锁骨下动脉并将动物放血至平均动脉压40毫米汞柱，在清醒大鼠中制造出血性休克，该血压维持1小时（早期休克）或2小时（晚期休克）。对膈肌（工作肌）的分析表明，从早期休克开始，三磷酸腺苷（ATP）、二磷酸腺苷（ADP）和磷酸肌酸水平就显著下降，而在比目鱼肌（静息肌）中，这些变化直到晚期休克才观察到。早期休克时，膈肌中腺嘌呤核苷酸的减少程度小于肝脏和肾脏等工作器官。这表明休克期间腺嘌呤核苷酸的减少程度可能与器官的代谢活性有关。
