Rasgon Natalie L, Rao Rekha C, Hwang Sun, Altshuler Lori L, Elman Shana, Zuckerbrow-Miller Joni, Korenman Stanley G
Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles School of Medicine, Mood Disorders Research Program, 300 Medical Plaza, Suite 1544, Los Angeles, CA 90095-7057, USA.
J Affect Disord. 2003 May;74(3):299-304. doi: 10.1016/s0165-0327(02)00117-9.
We assessed the prevalence of mood disturbance among women with prospectively documented polycystic ovary syndrome (PCOS).
Thirty-two women with PCOS completed the Center for Epidemiological Studies-Depression Rating Scale (CES-D). Clinical and biochemical characteristics were assessed.
Sixteen women had CES-D scores indicative of depression. Depression was associated with greater insulin resistance (P=0.02) and higher body mass index (P=0.05). Women receiving oral contraceptives for the treatment of PCOS were less depressed than patients not receiving treatment (P=0.03).
Possible selection bias, use of a screening tool alone without further diagnostic evaluation of depression, small samples size and lack of direct comparison with an age matched control group, should be considered in interpretation of these results.
Findings suggest a high prevalence of depression among women with PCOS, and an association between depression and PCOS markers.
我们评估了前瞻性记录有多囊卵巢综合征（PCOS）的女性中情绪障碍的患病率。
32名患有PCOS的女性完成了流行病学研究中心抑郁评定量表（CES-D）。评估了临床和生化特征。
16名女性的CES-D评分表明有抑郁症状。抑郁与更高的胰岛素抵抗（P = 0.02）和更高的体重指数（P = 0.05）相关。接受口服避孕药治疗PCOS的女性比未接受治疗的患者抑郁程度更低（P = 0.03）。
在解释这些结果时应考虑可能的选择偏倚、仅使用筛查工具而未对抑郁进行进一步诊断评估、样本量小以及缺乏与年龄匹配对照组的直接比较。
研究结果表明PCOS女性中抑郁症的患病率较高，且抑郁与PCOS标志物之间存在关联。
