Yuzuncu Yil University, Faculty of Medicine, Department of Psychiatry, Van, Turkey.
Department of Obstetrics and Gynecology, Ankara Training and Research Hospital, Ankara, Turkey.
Psychiatry Res. 2017 Dec;258:171-176. doi: 10.1016/j.psychres.2016.11.043. Epub 2016 Dec 3.
In this study, we aimed to examine the relationship between atypical depression and insulin resistance (IR) in patients with polycystic ovary syndrome (PCOS) and major depression. A total of 176 subjects (69 patients with PCOS, 58 patients with depression, and 49 healthy controls) were included in the study. The Beck Depression Inventory (BDI), the Beck Anxiety Inventory (BAI), the Beck Hopelessness Scale (BHS), and the Scale for Suicide Ideation (SSI) were administered. Data concerning their height, weight, fasting a.m. serum levels of insulin, glucose level, and total testosterone level were collected from all participants. The body mass index (BMI) and the Homeostasis Model Assessment Insulin Resistance index (HOMA-IR) were both calculated. 34 (49.3%) of the PCOS patients met the criteria for depression. 26 (76.5%) of them had atypical depression, 8 (23.5%) had non-atypical depression. 27 (46.6%) of the 58 depressed patients had atypical depression. Insulin resistance was higher in the PCOS patients than in the control subjects and the depression patients. There was no association between atypical depression and IR in patients with PCOS and depression. We concluded that there is no relationship between IR and atypical depression.
在这项研究中，我们旨在探讨多囊卵巢综合征（PCOS）伴发和非伴发抑郁症患者中不典型抑郁与胰岛素抵抗（IR）之间的关系。共纳入 176 名受试者（69 名 PCOS 患者，58 名抑郁症患者和 49 名健康对照者）。使用贝克抑郁量表（BDI）、贝克焦虑量表（BAI）、贝克绝望量表（BHS）和自杀意念量表（SSI）对受试者进行评估。收集所有参与者的身高、体重、空腹上午血清胰岛素、血糖和总睾酮水平数据。计算体重指数（BMI）和稳态模型评估胰岛素抵抗指数（HOMA-IR）。34 名（49.3%）PCOS 患者符合抑郁症标准。其中 26 名（76.5%）为不典型抑郁，8 名（23.5%）为非典型抑郁。58 名抑郁症患者中 27 名（46.6%）为不典型抑郁。PCOS 患者的胰岛素抵抗高于对照组和抑郁症患者。在 PCOS 伴发和非伴发抑郁症患者中，不典型抑郁与 IR 之间无相关性。我们得出结论，IR 与不典型抑郁之间无关系。
