Bissière Stephanie, Humeau Yann, Lüthi Andreas
Department of Pharmacology/Neurobiology, Biozentrum, University of Basel, Klingelbergstrasse 70, CH-4056 Basel, Switzerland.
Nat Neurosci. 2003 Jun;6(6):587-92. doi: 10.1038/nn1058.
Fear conditioning involves the induction of long-term potentiation (LTP) of excitatory synaptic transmission in the lateral amygdala, a brain structure which is tightly controlled by GABAergic inhibition. Here we show that dopamine gates the induction of LTP in the mouse lateral amygdala by suppressing feedforward inhibition from local interneurons. Our findings provide a cellular mechanism for the dopaminergic modulation of fear conditioning and indicate that suppression of feedforward inhibition represents a key mechanism for the induction of associative synaptic plasticity in the lateral amygdala.
恐惧条件反射涉及外侧杏仁核兴奋性突触传递的长时程增强（LTP）的诱导，外侧杏仁核是一个受γ-氨基丁酸能抑制严格控制的脑结构。在这里，我们表明多巴胺通过抑制局部中间神经元的前馈抑制来控制小鼠外侧杏仁核中LTP的诱导。我们的研究结果为恐惧条件反射的多巴胺能调节提供了一种细胞机制，并表明前馈抑制的抑制是外侧杏仁核中诱导联合突触可塑性的关键机制。
