Ma Yu, Yang Xiaolan, Tang Xianjue, Jing Shuhua
Department of Chemistry, Chongqing University of Medical Sciences, Chongqing 400016.
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2003 Mar;20(1):11-3.
The adsorption of methylene blue (MB) in plasma on cross-linked agarose beads entrapped activated charcoal (CAAC-I), cross-linked agarose coated activated charcoal (CAAC-II) and cross-linked agar beads entrapped attapulgite (CAA) was tested in this study. These adsorbents are intended to be applied to blood purification for eliminating MB from virucidal MB-phototrated plasma units. The experimental results indicated that the adsorption of MB in plasma on CAAC-I and CAA was quick and efficacious, but it was slower on CAAC-II. The relationship between the adsorption time and the adsorption rate was examined with reference to the plasma with a specific concentration of MB flowing over a certain volume of CAA. A flow rate of about 1 ml.min-1 through 10 ml CAA at 25 degrees C could eliminate more than 95% of the MB in 200 ml human plasma (1 mumol.L-1).
本研究测试了血浆中亚甲基蓝（MB）在交联琼脂糖珠包埋活性炭（CAAC-I）、交联琼脂糖包被活性炭（CAAC-II）和交联琼脂珠包埋凹凸棒石（CAA）上的吸附情况。这些吸附剂旨在应用于血液净化，以从灭病毒的MB光处理血浆单元中去除MB。实验结果表明，血浆中MB在CAAC-I和CAA上的吸附迅速且有效，但在CAAC-II上较慢。以特定浓度的MB血浆流过一定体积的CAA为参照，研究了吸附时间与吸附速率之间的关系。在25℃下，以约1 ml·min-1的流速通过10 ml CAA，可在200 ml人血浆（1 μmol·L-1）中去除超过95%的MB。
