Shi Xinyuan, Tan Tianwei
College of Chemical Engineering, Beijing University of Chemical Technology, Beijing 100029.
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2003 Mar;20(1):26-9.
In this work a system which consists of chitosan (CS) microcores entrapped within enteric polymer is presented. Vitamin D2, used as a model drug, was efficiently entrapped within CS microcores using spray-drying and then microencapsulated into ethylic cellulose(EC). The morphology and release properties of microcapsules were tested. The influential factors of preparation conditions included molecular weight of chitosan, concentration of chitosan solution, concentration of acetic acid, loading of vitamin D2 were discussed. The results of in vitro release studies showed that the microcapsules prepared in this article could realize sustained release in intestine.
