利用背散射光谱质心偏移对松质骨进行表征。
Characterization of trabecular bone using the backscattered spectral centroid shift.
作者信息
Wear Keith A
机构信息
U.S. Food and Drug Administration, Center for Devices and Radiological Health, Rockville, MD 20852, USA.
出版信息
IEEE Trans Ultrason Ferroelectr Freq Control. 2003 Apr;50(4):402-7. doi: 10.1109/tuffc.2003.1197963.
Ultrasonic attenuation in bone in vivo is generally measured using a through-transmission method at the calcaneus. Although attenuation in calcaneus has been demonstrated to be a useful predictor for osteoporotic fracture risk, measurements at other clinically important sites, such as hip and spine, could potentially contain additional useful diagnostic information. Through-transmission measurements may not be feasible at these sites due to complex bone shapes and the increased amount of intervening soft tissue. Centroid shift from the backscattered signal is an index of attenuation slope and has been used previously to characterize soft tissues. In this paper, centroid shift from signals backscattered from 30 trabecular bone samples in vitro were measured. Attenuation slope also was measured using a through-transmission method. The correlation coefficient between centroid shift and attenuation slope was -0.71. The 95% confidence interval was (-0.86, -0.47). These results suggest that the backscattered spectral centroid shift may contain useful diagnostic information potentially applicable to hip and spine.
体内骨骼的超声衰减通常采用跟骨的穿透传输法进行测量。尽管已证明跟骨衰减是骨质疏松性骨折风险的有用预测指标，但在其他临床重要部位（如髋部和脊柱）进行测量可能会包含额外有用的诊断信息。由于骨骼形状复杂以及中间软组织量增加，穿透传输测量在这些部位可能不可行。后向散射信号的质心偏移是衰减斜率的一个指标，此前已用于表征软组织。在本文中，测量了体外30个松质骨样本后向散射信号的质心偏移。还采用穿透传输法测量了衰减斜率。质心偏移与衰减斜率之间的相关系数为-0.71。95%置信区间为（-0.86，-0.47）。这些结果表明，后向散射频谱质心偏移可能包含潜在适用于髋部和脊柱的有用诊断信息。
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