Reid K H, Paskitti M, Guo S Z, Schmelzer T, Iyer V
Department of Anatomical Sciences and Neurobiology, University of Louisville, Louisville, KY 40292, USA.
Resuscitation. 2003 May;57(2):201-10. doi: 10.1016/s0300-9572(03)00025-x.
We review 7 years experience with the chest compression model of cardiac arrest and resuscitation, comparing two different anesthetics. Ketamine stimulates cardiac function and only mildly depresses respiration; of the two it provides easier resuscitation. However, ketamine severely depresses brain protein synthesis; in studies using this measure ketamine is unsuitable and another agent must be used. Sodium pentobarbital mildly depresses brain protein synthesis, but depresses both cardiac and respiratory function, making resuscitation more difficult. Use of alternate chest/abdominal pumping (Babbs resuscitation technique), with judicious use of intra-cardiac epinephrine (adrenaline), made resuscitation reliable under sodium pentobarbital as well.
我们回顾了7年心脏骤停与复苏胸外按压模型的经验，比较了两种不同的麻醉剂。氯胺酮可刺激心脏功能，仅轻微抑制呼吸；在这两种麻醉剂中，它使复苏更容易。然而，氯胺酮会严重抑制脑蛋白合成；在使用该指标的研究中，氯胺酮并不适用，必须使用其他药物。戊巴比妥钠轻度抑制脑蛋白合成，但会抑制心脏和呼吸功能，使复苏更加困难。交替进行胸部/腹部按压（巴布斯复苏技术），并谨慎使用心内肾上腺素（肾上腺素），在戊巴比妥钠麻醉下也能实现可靠的复苏。
