Lo T Y M, McPhillips M, Minns R A, Gibson R J
Clinical Research Fellow, Royal Hospital for Sick Children, Sciennes Road, Edinburgh EH9 1LF, Scotland, UK.
Pediatr Rehabil. 2003 Jan-Mar;6(1):47-55. doi: 10.1080/1363849031000109516.
To determine the frequency of cerebral atrophy and microcephaly in a group of children with sequential MRI brain scans after surviving a non-accidental head injury (n = 16).
Serial head circumference measurements (OFC) were extracted and plotted on standard growth charts for each child retrospectively to determine the frequency of secondary microcephaly. Cerebral atrophy was diagnosed and quantified by measurement of the ventricular/cortical ratio on coronal images of the sequential scans.
Acquired microcephaly was found in 15 children (93.8%) over a median follow-up period of 67.93 weeks. There was a significant reduction in the median Z-score for the OFC at the most recent follow-up when compared with that at presentation (p < 0.001, Wilcoxon Signed Rank Test). Cerebral atrophy was found to be the cause of the microcephaly in eight of the 15 children and was evident as early as 9 days after presentation.
A large proportion of the cohort (93.8%) develops acquired microcephaly after an inflicted head injury and cerebral atrophy is responsible in half of these cases.
确定一组非意外性头部损伤存活后接受序贯脑部MRI扫描的儿童中脑萎缩和小头畸形的发生率（n = 16）。
回顾性提取每个儿童的系列头围测量值（枕额径）并绘制在标准生长图表上，以确定继发性小头畸形的发生率。通过测量序贯扫描冠状图像上的脑室/皮质比来诊断和量化脑萎缩。
在中位随访期67.93周内，15名儿童（93.8%）出现获得性小头畸形。与就诊时相比，最近一次随访时枕额径的中位Z评分显著降低（p < 0.001，Wilcoxon符号秩检验）。在15名儿童中的8名中，脑萎缩被发现是小头畸形的原因，最早在就诊后9天就很明显。
该队列中的很大一部分（93.8%）在遭受头部损伤后出现获得性小头畸形，其中一半病例是由脑萎缩引起的。
