Cederblad G, Floderus A, Karlsson K E
Acta Physiol Scand. 1976 Apr;96(4):471-7. doi: 10.1111/j.1748-1716.1976.tb10216.x.
A digital computer program is described for the estimation of parameters in an open two compartment system distinguishing 3 models. The mathematical function to be fitted to a given set of experimental data is given initial estimates for the parameters of the function. The program uses an iterative procedure to adjust the parameters until the sum of squares of residuals has converged to a minimum. Assuming that a given substance is introduced into compartment 1, the function can be fitted to the set of experiment data of that compartment. A set of experimental data from compartment 2 can also be included in the minimizing function. Two optional weighting functions are presented. From the constants of the two-exponential functions the physiological parameters of the three models are determined. Experimental observations of compartment 1 only allow for calculation of physiological parameters of two of the models.
描述了一种数字计算机程序，用于估计区分三种模型的开放双室系统中的参数。要拟合到给定实验数据集的数学函数会给出该函数参数的初始估计值。该程序使用迭代过程来调整参数，直到残差平方和收敛到最小值。假设将给定物质引入隔室1，则该函数可以拟合到该隔室的实验数据集。来自隔室2的一组实验数据也可以包含在最小化函数中。给出了两个可选的加权函数。根据双指数函数的常数确定三种模型的生理参数。仅隔室1的实验观察结果仅允许计算其中两种模型的生理参数。
