So Loletta K-Y, Lau Arthur C W, Yam Loretta Y C, Cheung Thomas M T, Poon Edwin, Yung Raymond W H, Yuen K Y
Department of Medicine, Pamela Youde Nethersole Eastern Hospital, Hong Kong, Special Administrative Region, China.
Lancet. 2003 May 10;361(9369):1615-7. doi: 10.1016/s0140-6736(03)13265-5.
A series of 31 patients with probable SARS, diagnosed from WHO criteria, were treated according to a treatment protocol consisting of antibacterials and a combination of ribavirin and methylprednisolone. Through experience with the first 11 patients, we were able to finalise standard dose regimens, including pulsed methylprednisolone. One patient recovered on antibacterial treatment alone, 17 showed rapid and sustained responses, and 13 achieved improvement with step-up or pulsed methylprednisolone. Four patients required short periods of non-invasive ventilation. No patient required intubation or mechanical ventilation. There was no mortality or treatment morbidity in this series.
根据世界卫生组织标准诊断出的31例疑似严重急性呼吸综合征（SARS）患者，按照包含抗菌药物以及利巴韦林与甲泼尼龙联合用药的治疗方案进行治疗。通过对前11例患者的治疗经验，我们确定了标准剂量方案，包括冲击性甲泼尼龙治疗。1例患者仅通过抗菌治疗康复，17例患者显示出快速且持续的反应，13例患者通过逐步增加剂量或冲击性甲泼尼龙治疗病情得到改善。4例患者需要短期无创通气。无患者需要插管或机械通气。该组患者无死亡病例或治疗相关并发症。
