Kamath Amita, Smith Wade S, Powers William J, Cianfoni Alessandro, Chien Jeffrey D, Videen Tom, Lawton Michael T, Finley Bruce, Dillon William P, Wintermark Max
Department of Radiology, Neuroradiology Section, University of California, San Francisco, San Francisco, CA 94143-0628, USA.
Neuroradiology. 2008 Sep;50(9):745-51. doi: 10.1007/s00234-008-0403-9. Epub 2008 May 29.
The purpose of this study was to compare the results of perfusion computed tomography (PCT) with those of (15)O(2)/H(2) (15)O positron emission tomography (PET) in a subset of Carotid Occlusion Surgery Study (COSS) patients.
Six patients enrolled in the COSS underwent a standard-of-care PCT in addition to the (15)O(2)/H(2) (15)O PET study used for selection for extracranial-intracranial bypass surgery. PCT and PET studies were coregistered and then processed separately by different radiologists. Relative measurement of cerebral blood flow (CBF) and oxygen extraction fraction (OEF) were calculated from PET. PCT datasets were processed using different arterial input functions (AIF). Relative PCT and PET CBF values from matching regions of interest were compared using linear regression model to determine the most appropriate arterial input function for PCT. Also, PCT measurements using the most accurate AIF were evaluated for linear regression with respect to relative PET OEF values.
The most accurate PCT relative CBF maps with respect to the gold standard PET CBF were obtained when CBF values for each arterial territory are calculated using a dedicated AIF for each territory (R (2) = 0.796, p < 0.001). PCT mean transit time (MTT) is the parameter that showed the best correlation with the count-based PET OEF ratios (R (2) = 0.590, p < 0.001).
PCT relative CBF compares favorably to PET relative CBF in patients with chronic carotid occlusion when processed using a dedicated AIF for each territory. The PCT MTT parameter correlated best with PET relative OEF.
本研究的目的是在颈动脉闭塞手术研究（COSS）的一部分患者中比较灌注计算机断层扫描（PCT）与（15）O（2）/H（2）（15）O正电子发射断层扫描（PET）的结果。
纳入COSS的6例患者除了接受用于选择颅外 - 颅内搭桥手术的（15）O（2）/H（2）（15）O PET研究外，还接受了标准护理PCT。PCT和PET研究进行了配准，然后由不同的放射科医生分别处理。从PET计算脑血流量（CBF）和氧摄取分数（OEF）的相对测量值。使用不同的动脉输入函数（AIF）处理PCT数据集。使用线性回归模型比较匹配感兴趣区域的相对PCT和PET CBF值，以确定PCT最合适的动脉输入函数。此外，评估使用最准确AIF的PCT测量值与相对PET OEF值的线性回归。
当使用每个区域的专用AIF计算每个动脉区域的CBF值时，获得了相对于金标准PET CBF最准确的PCT相对CBF图（R（2）= 0.796，p <0.001）。PCT平均通过时间（MTT）是与基于计数的PET OEF比率显示最佳相关性的参数（R（2）= 0.590，p <0.001）。
在慢性颈动脉闭塞患者中，当使用每个区域的专用AIF进行处理时，PCT相对CBF与PET相对CBF相比具有优势。PCT MTT参数与PET相对OEF相关性最佳。
