Ramsey Scott D, Wilson Susan, Spencer Anna, Geidzinska Antoinette, Newcomb Polly
Fred Hutchinson Cancer Research Center, Public Health Sciences Division, 1100 Fairview Avenue North, MP-900, PO Box 19024, University of Washington, Seattle, WA 98109, USA.
Community Genet. 2003;6(1):29-36. doi: 10.1159/000069543.
To compare knowledge of and interest in genetic testing for hereditary colon cancer syndromes.
Colorectal cancer patients, first-degree relatives of colon cancer patients and controls were recruited from a familial cancer registry. Focus groups explored attitudes about genetic testing.
All three groups conveyed interest in testing, but lacked knowledge about testing and its implications. After receiving information regarding the potential benefits and costs of testing (including insurance and employment issues) all three groups were disinclined to be tested. The reasons varied among risk groups.
When informed about the costs and implications of testing, individuals may be reluctant to undergo genetic testing, regardless of baseline risk. Barriers to testing will vary depending on the perceived risk of carrying a mutation.
比较遗传性结肠癌综合征基因检测的知识和兴趣。
从家族癌症登记处招募结直肠癌患者、结直肠癌患者的一级亲属和对照组。焦点小组探讨了对基因检测的态度。
所有三组都表达了对检测的兴趣，但缺乏关于检测及其影响的知识。在收到关于检测的潜在益处和成本（包括保险和就业问题）的信息后，所有三组都不愿意接受检测。不同风险组的原因各不相同。
当了解检测的成本和影响时，个体可能不愿意接受基因检测，无论基线风险如何。检测的障碍将因对携带突变的感知风险而异。
